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Polyarginine Peptides As a New Class of Ligands of Nicotinic Acetylcholine Receptors

التفاصيل البيبلوغرافية
العنوان: Polyarginine Peptides As a New Class of Ligands of Nicotinic Acetylcholine Receptors
المؤلفون: V. I. Tsetlin, Igor E. Kasheverov, Natalya S. Egorova, D. A. Senko, Ekaterina N. Spirova, D. S. Lebedev, Igor Ivanov, Elena V. Kryukova
المصدر: Doklady Biochemistry and Biophysics. 483:313-315
بيانات النشر: Pleiades Publishing Ltd, 2018.
سنة النشر: 2018
مصطلحات موضوعية: 0301 basic medicine, alpha7 Nicotinic Acetylcholine Receptor, Arginine, Biophysics, Peptide, Ligands, Torpedo, complex mixtures, Biochemistry, law.invention, 03 medical and health sciences, chemistry.chemical_compound, law, Peptide synthesis, Animals, Receptor, Acetylcholine receptor, chemistry.chemical_classification, General Chemistry, General Medicine, Radioligand Assay, 030104 developmental biology, Nicotinic agonist, nervous system, chemistry, Peptides
الوصف: Arginine-containing peptides R3, R8, and R16 were obtained by solid-phase peptide synthesis, and their binding to nicotinic acetylcholine receptors (nAChRs) of muscle and neuronal (α7) types was studied by competitive radioligand assay with the use of 125I-α-bungarotoxin. The resulting peptides exhibited a significantly greater binding activity with respect to the muscle-type nAChRs than to the α7 receptor. Thus, we have discovered a new class of nAChR ligands. The affinity of the synthesized oligoarginines for nAChR depended on the number of amino acid residues in the chain. The highest affinity was exhibited by the R16 peptide, which contained 16 arginine residues.
تدمد: 1608-3091
1607-6729
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b3d0cde20dcd1c522da56dee7d0153
https://doi.org/10.1134/s1607672918060017
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....f9b3d0cde20dcd1c522da56dee7d0153
قاعدة البيانات: OpenAIRE
الوصف
تدمد:16083091
16076729