MicroRNA regulation of critical retinal pigment epithelial functions
| العنوان: | MicroRNA regulation of critical retinal pigment epithelial functions |
|---|---|
| المؤلفون: | Samuel W. Du, Krzysztof Palczewski |
| المصدر: | Trends in neurosciences, vol 45, iss 1 Trends Neurosci |
| بيانات النشر: | eScholarship, University of California, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cell physiology, genetic structures, Vision, 1.1 Normal biological development and functioning, Retinal Pigment Epithelium, Biology, Eye, Exosome, Article, Retina, noncoding RNA, chemistry.chemical_compound, Underpinning research, Ocular, microRNA, medicine, Genetics, Humans, exosome, oxidative stress, Psychology, Eye Disease and Disorders of Vision, Vision, Ocular, Retinal pigment epithelium, Neurology & Neurosurgery, General Neuroscience, Neurosciences, phagocytosis, Retinal, Non-coding RNA, gene therapy, eye diseases, MicroRNAs, medicine.anatomical_structure, chemistry, biomarker, Cognitive Sciences, sense organs, Neuroscience, Retinal Pigments, Biogenesis, Biotechnology |
| الوصف: | MicroRNAs are short, evolutionarily conserved noncoding RNAs that are critical for the control of normal cellular physiology. In the retina, photoreceptors are highly specialized neurons that transduce light into electrical signals. Photoreceptors, however, are unable to process visual stimuli without the support of the retinal pigment epithelium (RPE). The RPE performs numerous functions to aid the retina, including the generation of visual chromophore and metabolic support. Recent work has underscored how microRNAs enable vision through their contributions to RPE functions. This review focuses on the biogenesis and control of microRNAs in rodents and humans, the roles microRNAs play in RPE function and degeneration, and how microRNAs could serve as potential therapeutics and biomarkers for visual diseases. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0626d62ef2d5cfc3a67bcf2e9380a3 https://escholarship.org/uc/item/5b36z0bp |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fa0626d62ef2d5cfc3a67bcf2e9380a3 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |