Patient Preferences and Health State Utilities Associated with Mealtime Insulin Concentrations Among Patients with Diabetes in Italy
| العنوان: | Patient Preferences and Health State Utilities Associated with Mealtime Insulin Concentrations Among Patients with Diabetes in Italy |
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| المؤلفون: | Hayley Karn, Louis S. Matza, Jessica B Jordan, Silvia Del Santo, Beatrice Osumili, Gordon Parola, Katie D. Stewart, Serena Losi, Giovanni Biricolti, Magaly Perez-Nieves, Kristina S. Boye, Erik Spaepen, Ester Romoli |
| المصدر: | Diabetes Therapy |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Bioequivalence, Time-trade-off, 03 medical and health sciences, 0302 clinical medicine, Utility, Quality of life, Diabetes mellitus, Internal Medicine, medicine, Patient preference, Insulin concentration, business.industry, Brief Report, Insulin, Time trade-off, medicine.disease, Health states, Italy, business, Demography |
| الوصف: | Introduction Standard concentration (100 units/mL) mealtime insulin is frequently used to treat patients with type 1 (T1D) and type 2 diabetes (T2D). A more concentrated version of the medication (200 units/mL) has been available in Italy since 2016. This concentrated version is bioequivalent to the standard version and delivers the same amount of medication but in half the volume of liquid. The purpose of this study was to examine patient preferences and estimate health state utilities associated with standard and concentrated rapid-acting mealtime analog insulin. Methods Participants with T1D and T2D in Italy valued two health states in time trade-off interviews. The descriptions of diabetes and treatment in the two health states were identical, differing only in terms of insulin concentration (e.g., half as much liquid for the same dose, less effort needed to press the injection button, and fewer injection pens required with concentrated insulin). To ensure participants understood the health states, they were shown a short video illustrating the differences between concentrations. Results A total of 217 participants completed the interviews (49.8% male; mean age 56.1 years; 109 from Milan; 108 from Rome; 12.0% T1D; 88.0% T2D). When asked which health state they preferred, 98.2% responded the concentrated version, 0.9% said the standard version, and 0.9% had no preference. Mean [standard deviation (SD)] utilities rounded to three decimals were 0.892 (0.099) for the concentrated version and 0.884 (0.101) for the standard version. The mean (SD; p value) utility difference between the standard and concentrated rapid-acting insulin was 0.007 (0.019; p |
| تدمد: | 1869-6961 1869-6953 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4cd6962e871efa79e03ffd5b58a0f8 https://doi.org/10.1007/s13300-019-00718-8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fa4cd6962e871efa79e03ffd5b58a0f8 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18696961 18696953 |
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