MYC Ran Up the Clock: The Complex Interplay between MYC and the Molecular Circadian Clock in Cancer
| العنوان: | MYC Ran Up the Clock: The Complex Interplay between MYC and the Molecular Circadian Clock in Cancer |
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| المؤلفون: | Brian J. Altman, Amelia M Knudsen-Clark, Jamison B Burchett |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 7761, p 7761 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, circadian rhythm, Transcription, Genetic, QH301-705.5, Carcinogenesis, Circadian clock, cancer metabolism, Review, MYC, Biology, Catalysis, Inorganic Chemistry, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, 0302 clinical medicine, computational biology, Circadian Clocks, Neoplasms, medicine, cancer, Animals, Humans, Circadian rhythm, tumor immunology, Physical and Theoretical Chemistry, Biology (General), Molecular clock, Molecular Biology, Transcription factor, QD1-999, Spectroscopy, transcription factor, Organic Chemistry, Cancer, molecular clock, General Medicine, Period Circadian Proteins, medicine.disease, Chromatin, Computer Science Applications, Cell biology, Chemistry, 030104 developmental biology, 030220 oncology & carcinogenesis, Ran, Cancer cell, pause release |
| الوصف: | The MYC oncoprotein and its family members N-MYC and L-MYC are known to drive a wide variety of human cancers. Emerging evidence suggests that MYC has a bi-directional relationship with the molecular clock in cancer. The molecular clock is responsible for circadian (~24 h) rhythms in most eukaryotic cells and organisms, as a mechanism to adapt to light/dark cycles. Disruption of human circadian rhythms, such as through shift work, may serve as a risk factor for cancer, but connections with oncogenic drivers such as MYC were previously not well understood. In this review, we examine recent evidence that MYC in cancer cells can disrupt the molecular clock; and conversely, that molecular clock disruption in cancer can deregulate and elevate MYC. Since MYC and the molecular clock control many of the same processes, we then consider competition between MYC and the molecular clock in several select aspects of tumor biology, including chromatin state, global transcriptional profile, metabolic rewiring, and immune infiltrate in the tumor. Finally, we discuss how the molecular clock can be monitored or diagnosed in human tumors, and how MYC inhibition could potentially restore molecular clock function. Further study of the relationship between the molecular clock and MYC in cancer may reveal previously unsuspected vulnerabilities which could lead to new treatment strategies. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa54d6b60396bd5db37d123fcd4ee943 http://europepmc.org/articles/PMC8305799 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fa54d6b60396bd5db37d123fcd4ee943 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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