In-stent Restenosis in Bare Metal Stents Versus Sirolimus-eluting Stents After Primary Coronary Intervention for Acute Myocardial Infarction and Subsequent Transcoronary Transplantation of Autologous Stem Cells
| العنوان: | In-stent Restenosis in Bare Metal Stents Versus Sirolimus-eluting Stents After Primary Coronary Intervention for Acute Myocardial Infarction and Subsequent Transcoronary Transplantation of Autologous Stem Cells |
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| المؤلفون: | Kurt Sihorsch, Juergen Kammler, Alexander Kypta, Michael Grund, Clemens Steinwender, Franz Leisch, Christian Gabriel, Robert Hofmann, Klaus Kerschner |
| المصدر: | Clinical Cardiology. 31:356-359 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, Myocardial Infarction, Clinical Investigations, Anterior Descending Coronary Artery, Coronary Restenosis, Restenosis, Internal medicine, Granulocyte Colony-Stimulating Factor, medicine, Humans, cardiovascular diseases, Myocardial infarction, Antibacterial agent, Sirolimus, medicine.diagnostic_test, business.industry, digestive, oral, and skin physiology, Drug-Eluting Stents, General Medicine, Middle Aged, equipment and supplies, medicine.disease, Surgery, Transplantation, stomatognathic diseases, surgical procedures, operative, Drug-eluting stent, Angiography, Cardiology, Female, Stents, Cardiology and Cardiovascular Medicine, business, Stem Cell Transplantation, medicine.drug |
| الوصف: | Background Following stenting for acute myocardial infarction, transcoronary transplantation of granulocyte-colony stimulating factor (G-CSF) mobilized autologous stem cells (ASC) has been shown to result in an increased in-stent restenosis rate of bare metal stents (BMS). Hypothesis This study sought to compare the extent of neointimal growth in BMS and sirolimus-eluting stents (SES) after primary implantation, and subsequent transcoronary transplantation of G-CSF mobilized stem cells. Methods Patients with stenting of the left anterior descending coronary artery for acute anterior myocardial infarction were randomly assigned to receive a BMS or SES. Intracoronary stem cell injection was performed after G-CSF application for at least 4 d and cell apheresis. The angiograms obtained after cell transplantation and after 6 mo were analyzed by quantitative coronary angiography. Results We performed primary stenting and stem cell transplantion in 16 patients who received a BMS (n = 8) or an SES (n = 8). In 2 patients with a BMS, late stent thrombosis occurred after 58 d and 177 d, respectively. In the remaining patients, control angiography after 6 mo revealed in-stent restenosis of >50% in no patients with SES but in 4 patients with BMS (67%). Late lumen loss and in-stent plaque volume were significantly higher in patients with BMS compared with patients with SES. Conclusions Compared with BMS, SES impair in-stent intima hyperplasia after stenting for acute myocardial infarction and transcoronary transplantation of G-CSF mobilized ASC. Copyright © 2008 Wiley Periodicals, Inc. |
| تدمد: | 1932-8737 0160-9289 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa67a5a3a98c9d7c04e142809971d598 https://doi.org/10.1002/clc.20235 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fa67a5a3a98c9d7c04e142809971d598 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19328737 01609289 |
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