Epidemiology and outcomes of bloodstream infections in severe burn patients: a six-year retrospective study
| العنوان: | Epidemiology and outcomes of bloodstream infections in severe burn patients: a six-year retrospective study |
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| المؤلفون: | Lingcheng Xu, Haibin Dai, Gensheng Zhang, Danyang Li, Yiwen Sang, Yuping Hu, Yangmin Hu |
| المصدر: | Antimicrobial Resistance and Infection Control, Vol 10, Iss 1, Pp 1-8 (2021) Antimicrobial Resistance and Infection Control |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Acinetobacter baumannii, Male, medicine.medical_treatment, Bacteremia, Infectious and parasitic diseases, RC109-216, Multidrug resistance, Logistic regression, 0302 clinical medicine, Risk Factors, Drug Resistance, Multiple, Bacterial, Epidemiology, Central Venous Catheters, Pharmacology (medical), 030212 general & internal medicine, Hospital Mortality, Middle Aged, Klebsiella pneumoniae, Infectious Diseases, Female, Burns, Central venous catheter, Microbiology (medical), Adult, Methicillin-Resistant Staphylococcus aureus, medicine.medical_specialty, China, Bloodstream infection, 03 medical and health sciences, Internal medicine, medicine, Humans, Mortality, Survival analysis, Proportional Hazards Models, Retrospective Studies, Septic shock, business.industry, Proportional hazards model, Research, Public Health, Environmental and Occupational Health, 030208 emergency & critical care medicine, Retrospective cohort study, Length of Stay, medicine.disease, bacterial infections and mycoses, Respiration, Artificial, Logistic Models, Multivariate Analysis, business, Total body surface area, human activities |
| الوصف: | Background Infection is the leading cause of morbidity and mortality among burn patients, and bloodstream infection (BSI) is the most serious. This study aimed to evaluate the epidemiology and clinical outcomes of BSI in severe burn patients. Methods Clinical variables of all patients admitted with severe burns (≥ 20% total body surface area, %TBSA) were analyzed retrospectively from January 2013 to December 2018 at a teaching hospital. The Kaplan–Meier method was utilized for plotting survival curves. Multivariate logistic regression and Cox regression model were also performed. Results A total of 495 patients were evaluated, of whom 136 (27.5%) had a BSI. The median time from the patients being burned to BSI was 8 days. For BSI onset in these patients, 47.8% (65/136) occurred in the first week. The most frequently isolated causative organism was A. baumannii (22.7%), followed by methicillin-resistant Staphylococcus aureus (18.7%) and K. pneumoniae (18.2%), in patients with BSI. Multivariate logistic regression analysis showed that %TBSA (p = 0.023), mechanical ventilation (p = 0.019), central venous catheter (CVC) (p p p = 0.003) and septic shock (HR, 4.36; 95% CI 1.16–16.34; p = 0.031) were identified as independent predictors of 30-day mortality of BSI in burn patients. Conclusions Multidrug resistant gram-negative bacteria were the main pathogens of BSI in severe burn patients. Accurate evaluation of risk factors for BSI and the mortality of BSI in severe burn patients may improve early appropriate management. |
| اللغة: | English |
| تدمد: | 2047-2994 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa77eb733f93de254fd8f1c52a29dc78 https://doaj.org/article/85e12b5baba1432b858f7988bedce086 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fa77eb733f93de254fd8f1c52a29dc78 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20472994 |
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