Optimal Candidates to Do Fresh Embryo Transfer in Those Using Oral Contraceptive Pretreatment in IVF Cycles
| العنوان: | Optimal Candidates to Do Fresh Embryo Transfer in Those Using Oral Contraceptive Pretreatment in IVF Cycles |
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| المؤلفون: | Yao Lu, Yichao Niu, Yuan Wang, Yaqiong He, Ying Ding, Xinyuan Lu, Bing Xu, Steven R. Lindheim, Yun Sun |
| المصدر: | Frontiers in Physiology Frontiers in Physiology, Vol 12 (2021) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Infertility, endocrine system, Physiology, medicine.medical_treatment, Gonadotropin-releasing hormone, Cryopreservation, lcsh:Physiology, Andrology, 03 medical and health sciences, Basal (phylogenetics), 0302 clinical medicine, oral contraceptive, Physiology (medical), medicine, GnRH antagonist, GnRH agonist, Original Research, Pregnancy, fresh embryo transfer, 030219 obstetrics & reproductive medicine, In vitro fertilisation, lcsh:QP1-981, business.industry, Embryo, medicine.disease, 030104 developmental biology, Live birth, business, in vitro fertilization, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | ObjectiveConcern regarding the adverse impact of pretreatment of oral contraceptives (OC) prior to ovarian stimulation for in vitro fertilization (IVF) on pregnancy outcome has been debated. We investigated factors that may be associated with live birth rate (LBR) in fresh embryo transfer cycles after OC pretreatment.MethodsA retrospective study was conducted at the Reproductive Center of Ren Ji Hospital, Shanghai, China. 814 women aged 20–35 years undergoing their first autologous IVF cycle and fresh embryo transfer after OC pretreatment were included. Long gonadotropin releasing hormone (GnRH) agonist (a) or GnRH antagonist (ant) protocol was used for ovarian stimulation. Predictive factors for LBR were identified using multivariate logistic regression analysis.ResultsMultivariate logistic regression analysis demonstrated that using GnRH-ant protocol for ovarian stimulation was associated with significantly lower LBR (OR 0.70, 95% CI 0.52–0.93), while endometrial thickness on day of hCG trigger was associated with increased LBR (OR 1.16, 95% CI 1.06–1.27). Despite comparable patients’ age, duration of infertility, BMI and basal FSH between GnRH-a and GnRH-ant groups, those using GnRH-ant resulted in significantly lower LBR compared to the GnRH-a group (37.4 vs. 48.5%, p = 0.002). Using ROC analysis and a cut-off endometrial thickness of < and ≥ 9.5 mm, those < 9.5 mm using GnRH-ant resulted in significantly lower LBR (28.5 vs. 43.4%, p = 0.004), while no differences were noted with an endometrial thickness ≥9.5 mm (49.6 vs. 51.1%, p = 0.78).ConclusionsLive birth was significantly impacted in OC pre-treated GnRH-ant cycles with an endometrial thickness of |
| تدمد: | 1664-042X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7a5aeab9aa04dc0af3e76243e6900a https://pubmed.ncbi.nlm.nih.gov/33776782 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fa7a5aeab9aa04dc0af3e76243e6900a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1664042X |
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