Blood pressure overshoot after tilt reversal in patients with familial amyloidotic polyneuropathy
| العنوان: | Blood pressure overshoot after tilt reversal in patients with familial amyloidotic polyneuropathy |
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| المؤلفون: | Urban Wiklund, Rolf Hörnsten, Marcus Karlsson, Ole B. Suhr, Yukio Ando, Konen Obayashi, Sadahisa Okamoto |
| المصدر: | Hypertension Research. 34:133-138 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | congenital, hereditary, and neonatal diseases and abnormalities, Physiology, Hemodynamics, Blood Pressure, Autonomic Nervous System, Statistics, Nonparametric, Electrocardiography, Heart Rate, Tilt-Table Test, Internal Medicine, Overshoot (microwave communication), Humans, Medicine, In patient, Postural Balance, Aged, Amyloid Neuropathies, Familial, business.industry, Middle Aged, medicine.disease, digestive system diseases, Pathophysiology, Autonomic nervous system, Tilt (optics), Blood pressure, Anesthesia, Linear Models, Cardiology and Cardiovascular Medicine, business, Polyneuropathy |
| الوصف: | The pathophysiology of the hemodynamic responses to postural stress in familial amyloidotic polyneuropathy (FAP) remains to be elucidated. The aim of the study was to evaluate hemodynamic responses after tilt reversal in FAP. Systolic blood pressure (BP) and heart rate variability (HRV) were analyzed in the baseline, 70° upright position, and after tilt reversal in 15 FAP patients and 14 healthy controls. Beat-to-beat BP was recorded with a Finapres device. Maximum systolic BP after tilt reversal was increased with 22 ± 13 mm Hg in FAP patients as compared with baseline (BP overshoot), whereas controls showed a significantly lower BP overshoot (8 ± 6 mm Hg, P0.001). In all states, total spectral power and the power of the low and high frequency components were all significantly lower than those of the controls (P0.01). In a linear regression analysis adjusted for age, we found a significant inverse relation between BP overshoot and HRV (total spectral power, power of the low-frequency and high-frequency components) in all three states (standardized β between -0.74 to -0.53, P0.01). Five FAP patients presented a trial arrhythmia precluding HRV analysis: four of those presented BP overshoots ≥ 12 mm Hg. BP overshoot may be a marker to assess the progression of cardiac autonomic dysfunction, especially as heart arrhythmia in many FAP patients prevent HRV analysis. In addition, assessment of the post-tilt BP reaction points to possible treatment modalities for orthostatic hypotension at least in the early stages of the disease. |
| تدمد: | 1348-4214 0916-9636 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf1b7565e2e5b93f7e22d6bf5c3e3b4 https://doi.org/10.1038/hr.2010.181 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....faf1b7565e2e5b93f7e22d6bf5c3e3b4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13484214 09169636 |
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