Expression of Regeneration and Tolerance Factor Correlates Directly with Human Immunodeficiency Virus Infection and Inversely with Hepatitis C Virus Infection
| العنوان: | Expression of Regeneration and Tolerance Factor Correlates Directly with Human Immunodeficiency Virus Infection and Inversely with Hepatitis C Virus Infection |
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| المؤلفون: | Alice Gilman-Sachs, Jonathan S. Boomer, Kenneth D. Beaman, Maxwell P. Westerman, Brian K. DuChateau, C. C. Sung, M. R. Lepe, Tara S. Givens, Axel Feller, Antonio Chedid |
| المصدر: | Clinical Diagnostic Laboratory Immunology. 7:200-205 |
| بيانات النشر: | American Society for Microbiology, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Male, Microbiology (medical), CD3 Complex, T-Lymphocytes, Hepatitis C virus, CD3, Clinical Biochemistry, Immunology, HIV Infections, CD8-Positive T-Lymphocytes, Pregnancy Proteins, CD38, Lymphocyte Activation, medicine.disease_cause, Mice, NAD+ Nucleosidase, Immune system, Downregulation and upregulation, Antigens, CD, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, Suppressor Factors, Immunologic, medicine, Animals, Humans, Immunology and Allergy, ADP-ribosyl Cyclase, Mice, Inbred BALB C, Membrane Glycoproteins, biology, virus diseases, HLA-DR Antigens, Hepatitis C, NAD+ nucleosidase, medicine.disease, ADP-ribosyl Cyclase 1, Antigens, Differentiation, Virology, digestive system diseases, Membrane glycoproteins, ComputingMethodologies_PATTERNRECOGNITION, Immune-Mediated Responses and Disorders, biology.protein, Female |
| الوصف: | Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) cause two of the most prevalent debilitating viral infections. HIV appears to induce a skewing toward a Th2 response, while in HCV infection a Th1 response appears to dominate. Regeneration and tolerance factor (RTF) may participate in driving or sustaining a Th2 cytokine response. The expression of RTF on CD3+T cells of HIV-seropositive (HIV+) individuals is increased. The purpose of this study was to compare the expression of RTF during HIV infections with that during HCV infections. Three-color flow-cytometric analysis of peripheral blood collected from HIV+HCV-seropositive (HCV+), HIV- and HCV-seropositive (HIV+HCV+), and HIV- and HCV-seronegative (HIV−HCV−) individuals was performed. Levels of RTF expression on T-lymphocyte subsets from these groups were compared, as were levels of RTF expression on activated T cells expressing CD38 and HLA-DR, to determine the relationship of RTF expression to these infections. We demonstrated that the expression of RTF on surfaces of T cells from HIV+individuals is upregulated and that its expression on T cells from HCV+individuals is downregulated. A twofold increase in the mean channel fluorescence of RTF on CD3+T cells was seen in both HIV+and HIV+HCV+individuals compared to HIV−HCV−individuals. HCV+individuals had lower levels of RTF expression than HIV−HCV−individuals (P< 0.005 for CD4+;P< 0.0005 for CD8+). In terms of percentages of T cells expressing RTF, the groups were ranked as follows: HIV+> HIV+HCV+> HIV−HCV−> HCV+. The results indicate that RTF expression correlates with HIV-associated immune activation and may be associated with Th2-type responses. |
| تدمد: | 1098-6588 1071-412X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf663c69206d4bcfa41a6739230b21a https://doi.org/10.1128/cdli.7.2.200-205.2000 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....faf663c69206d4bcfa41a6739230b21a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986588 1071412X |
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