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Haibo Teng,1,* Zhiyong Liu,1,* Ouying Yan,2 Wenbo He,1 Danyang Jie,3 Yuanwei Qie,4 Jianguo Xu1 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Peopleâs Republic of China; 2The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, Peopleâs Republic of China; 3West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Peopleâs Republic of China; 4Health Management Center of West-China Fourth Hospital, Sichuan University, Chengdu, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Jianguo XuDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Peopleâs Republic of ChinaEmail xujg@scu.edu.cnBackground: Craniopharyngiomas (CPs) are relatively rare benign tumor located in the central nervous system (CNS). This study investigates the related risk factors of survival of craniopharyngiomas and develops a simple but detailed method predicting prognosis based on the Surveillance, Epidemiology, and End Results (SEER) database in order to improve the clinic management of CPs.Methods: Between 2004 and 2017, 1213 patients diagnosed with craniopharyngiomas registered at the program and were included in the SEER-21 registry database. Overall survival (OS) curves were plotted with the KaplanâMeier method and significance was determined by Log rank test. Single- and multiple-factor regression analyses were made using Cox proportional hazards model to identify independent predictors related to OS. Subsequently, we developed a nomogram with those factors to predict 3-, 5- and 10-year OS of craniopharyngiomas patients.Results: We identified 1213 patients with craniopharyngioma. The OS rates at 3, 5, and 10 years after diagnosis were 89.1%, 86.2%, and 83%. Age, ethnicity, tumor size and radiation therapy were confirmed to be predictors correlating with OS at initial diagnosis. In multivariate analysis, we found that younger age (P< 0.001), smaller tumor size (P< 0.001), white ethnicity (P< 0.001) and radiation therapy (P=0.004) were the factors that remained significantly associated with better survival. A nomogram was successfully constructed and validated by ROC, calibration plots and C-index of 0.773 (95% CI, 0.708â 0.838).Conclusion: The well-calibrated nomogram is the first clinical prediction model for predicting the prognosis for patients with craniopharyngiomas at initial diagnosis. Our study indicates that the surgical effect is not clear. Younger white patients with radiotherapy have a better prognosis, and the gross total resection (GTR) was not effective in prolonging the OS of a patient compared to no surgery and subtotal resection (STR).Keywords: craniopharyngioma, nomogram, overall survival, SEER |
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