Nuclear Factor Erythroid 2-Related Factor 2-Histone Deacetylase 2 Pathway in the Pathogenesis of Refractory Sudden Sensorineural Hearing Loss and Glucocorticoid Resistance
| العنوان: | Nuclear Factor Erythroid 2-Related Factor 2-Histone Deacetylase 2 Pathway in the Pathogenesis of Refractory Sudden Sensorineural Hearing Loss and Glucocorticoid Resistance |
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| المؤلفون: | Jie Hou, Yanhong Dai, Wei Ma, Wandong She, Ziwen Gao, Qiongqiong Zhou, Hui Qi |
| المصدر: | ORL J Otorhinolaryngol Relat Spec |
| بيانات النشر: | S. Karger AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, NF-E2-Related Factor 2, Hearing loss, Hearing Loss, Sensorineural, Histone Deacetylase 2, Peripheral blood mononuclear cell, Pathogenesis, Refractory, Internal medicine, medicine, Humans, Glucocorticoids, medicine.diagnostic_test, business.industry, Histone deacetylase 2, Hearing Loss, Sudden, medicine.disease, Treatment Outcome, Endocrinology, Otorhinolaryngology, Leukocytes, Mononuclear, Audiometry, Pure-Tone, Hearing test, Sensorineural hearing loss, medicine.symptom, business, Glucocorticoid, Research Article, medicine.drug |
| الوصف: | Introduction: A significant number of sensorineural hearing loss (SSNHL) patients had no noticeable hearing improvement after glucocorticoid (GC) treatment. In the present study, we examined expression of the nuclear factor erythroid 2-related factor 2 (NRF2) and histone deacetylase 2 (HDAC2) in peripheral blood mononuclear cells (PBMCs) of refractory SSNHL patients to study the role of NRF2-HDAC2 pathway in GC insensitivity hearing improvement after GC treatment, which is usually referred to as refractory SSNHL or GC insensitivity. Materials and Methods: Forty-four refractory SSNHL patients were treated by intratympanic GC infusion. Hearing was tested in all patients before and after treatment by pure tone hearing test. NRF2/HDAC2 mRNA and protein levels were examined in PBMCs of refractory SSNHL patients before and after treatment. PBMCs from healthy volunteers were used as normal controls. Results: According to the hearing improvement after treatment, patients were assigned into 2 groups: the intratympanic GC sensitive (IGCS) group (hearing recovery ≥15 dB HL) and the intratympanic GC insensitive (IGCI) group (hearing recovery Conclusion: Low response of NRF2/HDAC2 proteins is associated with GC insensitivity in SSNHL. We speculate that the NRF2-HDAC2 pathway affects GC sensitivity in SSNHL patients. |
| تدمد: | 1423-0275 0301-1569 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb14cef929616884b7ff85127da71795 https://doi.org/10.1159/000515205 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fb14cef929616884b7ff85127da71795 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230275 03011569 |
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