Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: Orally effective anti-inflammatory drug candidates
| العنوان: | Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: Orally effective anti-inflammatory drug candidates |
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| المؤلفون: | Carolina D. Duarte, Carlos A. M. Fraga, Newton G. Castro, Nelilma C. Romeiro, Javier Ellena, Jorge L. M. Tributino, Eliezer J. Barreiro, Ana L.P. Miranda, Rodrigo S. Corrêa, Antonio C. Doriguetto |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Elsevier BV, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Drug, medicine.drug_class, media_common.quotation_subject, Clinical Biochemistry, Analgesic, Administration, Oral, Pharmaceutical Science, Pharmacology, Carrageenan, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Anti-inflammatory, Oral administration, In vivo, Edema, Drug Discovery, medicine, Animals, Computer Simulation, Cyclooxygenase Inhibitors, Benzodioxoles, Rats, Wistar, Molecular Biology, media_common, biology, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, Hydrazones, Rats, FARMACODINÂMICA, Disease Models, Animal, Enzyme inhibitor, biology.protein, Thermodynamics, Molecular Medicine, Female, medicine.symptom |
| الوصف: | We described herein the molecular design of novel in vivo anti-inflammatory 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives (1) planned by applying the molecular hybridization approach. This work also points out to the discovery of LASSBio-930 (1c) as a novel anti-inflammatory and anti-hyperalgesic prototype, which was able to reduce carrageenan-induced rat paw edema with an ED(50) of 97.8 micromol/kg, acting mainly as a non-selective COX inhibitor. |
| تدمد: | 0968-0896 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb28b8ea28c186a964cd515aa6987269 https://doi.org/10.1016/j.bmc.2008.12.045 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fb28b8ea28c186a964cd515aa6987269 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09680896 |
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