Biomedical applications of electrospun nanofibers in the management of diabetic wounds
| العنوان: | Biomedical applications of electrospun nanofibers in the management of diabetic wounds |
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| المؤلفون: | Vyshnavi Tallapaneni, Sachin Kumar Singh, Veera Venkata Satyanarayana Reddy Karri, Divya Pamu |
| المصدر: | Drug Delivery and Translational Research. 12:158-166 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, Nanofibers, Complex disease, Pharmaceutical Science, 02 engineering and technology, 030226 pharmacology & pharmacy, Diabetic wound, 03 medical and health sciences, 0302 clinical medicine, Electrospun nanofibers, Diabetes mellitus, Diabetes Mellitus, medicine, Humans, Intensive care medicine, Wound Healing, Debridement, business.industry, Hydrogels, 021001 nanoscience & nanotechnology, medicine.disease, Bandages, Anti-Bacterial Agents, Nanofiber, Self-healing hydrogels, 0210 nano-technology, Wound healing, business |
| الوصف: | Diabetes mellitus (DM) is a complex disease that affects almost all the body's vital organs. Around 415 million people have been diagnosed with DM worldwide, and most of them are due to type 2 DM. The incidence of DM is estimated to increase by 642 million individuals by 2040. DM is considered to have many complications among which diabetic wound (DW) is one of the most distressing complication. DW affects 15% of people with diabetes and is triggered by the loss of glycaemic control, peripheral neuropathy, vascular diseases, and immunosuppression. For timely treatment, early detection, debridement, offloading, and controlling infection are crucial. Even though several treatments are available, the understanding of overlying diabetes-related wound healing mechanisms as therapeutic options has increased dramatically over the past decades. Conventional dressings are cost-effective; however, they are not productive enough to promote the overall process of DW healing. Thanks to tissue engineering developments, one of the promising current trends in innovative wound dressings such as hydrocolloids, hydrogels, scaffolds, films, and nanofibers which merges traditional healing agents and modern products/practices. Nanofibers prepared by electrospinning with enormous porosity, excellent absorption of moisture, the better exchange rate of oxygen, and antibacterial activities have increased interest. The application of these nanofibers can be extended by starting with a careful selection of polymers, loading with active therapeutic moieties such as peptides, proteins, active pharmaceutical ingredients (API), and stem cells, etc. to make them as potential dosage forms in the management of DWs. This review explains the potential applications of electrospun nanofibers in DW healing. A schematic view of role of nanofibers in diabetic wounds. |
| تدمد: | 2190-3948 2190-393X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2fec9e645ad880a70c3ad9193f4e05 https://doi.org/10.1007/s13346-021-00941-6 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....fb2fec9e645ad880a70c3ad9193f4e05 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 21903948 2190393X |
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