The Effect of Resveratrol on Surgery-Induced Epidural Fibrosis in Laminectomy Rats
| العنوان: | The Effect of Resveratrol on Surgery-Induced Epidural Fibrosis in Laminectomy Rats |
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| المؤلفون: | Zhenfeng Li, Hongmei Xin, Peng Xu, Peifeng Sun, Jianmin Li, Bo Miao, Guofeng Xia, Jinzhu Zhao, Jian Hu |
| المصدر: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2014 (2014) |
| بيانات النشر: | Hindawi Publishing Corporation, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, Article Subject, biology, business.industry, medicine.medical_treatment, Laminectomy, Vimentin, lcsh:Other systems of medicine, Epidural fibrosis, Resveratrol, lcsh:RZ201-999, Surgery, chemistry.chemical_compound, Hydroxyproline, Complementary and alternative medicine, chemistry, medicine, biology.protein, Inflammatory factors, Complication, business, Saline, Research Article |
| الوصف: | Epidural fibrosis (EF) is a common complication for the patients who underwent laminectomy. Recently, EF is thought to cause recurrent postoperative pain after laminectomy. Resveratrol has been shown to exert its anti-inflammatory, antifibrotic, and antiproliferative multifaceted properties. The object of this study was to investigate the effects of resveratrol on the prevention of postlaminectomy EF formation in laminectomy rats. A controlled double-blinded study was performed on 60 healthy adult Sprague-Dawley rats that underwent lumbar laminectomy at the L1-L2 levels. They were divided randomly into 3 groups (1, 2, and 3) of 20 rats each—group 1: resveratrol treatment group; group 2: resveratrol dilution saline treatment group; group 3: sham group (rats underwent laminectomy without treatment). All rats were killed 4 weeks after operation. The Rydell score, hydroxyproline content, vimentin cells density, fibroblasts density, and inflammatory factors expressional levels all suggested better results in resveratrol group than the other two groups. Resveratrol is able to inhibit fibroblasts proliferation, and TGF-β1 and IL-6 expressions and prevent epidural fibrosis in postlaminectomy rat. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1741-4288 1741-427X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6020b00b766a3246a35339e0f88eb9 http://europepmc.org/articles/PMC3982460 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fb6020b00b766a3246a35339e0f88eb9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17414288 1741427X |
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