Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B
| العنوان: | Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B |
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| المؤلفون: | Ling Ren, Lingyang Xu, Yahui Wang, Xing Fu, Xin Hu, Lupei Zhang, Junya Li, Luc Willems, Qian Li, Qiyuan Yang, Yishen Xing |
| المصدر: | Animals, Vol 9, Iss 11, p 859 (2019) Animals Volume 9 Issue 11 |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cellular differentiation, proliferation, Biology, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Gene expression, microRNA, lcsh:Zoology, medicine, fetal skeletal muscle, lcsh:QL1-991, Progenitor cell, ACVR1B, 030304 developmental biology, 0303 health sciences, lcsh:Veterinary medicine, General Veterinary, Myogenesis, bovine, Skeletal muscle, differentiation, Cell biology, acvr1b, medicine.anatomical_structure, bta-mir-24-3p, 030220 oncology & carcinogenesis, embryonic structures, lcsh:SF600-1100, Animal Science and Zoology |
| الوصف: | MicroRNAs modulate a variety of cellular events, including skeletal muscle development, but the molecular basis of their functions in fetal bovine skeletal muscle development is poorly understood. In this study, we report that bta-miR-24-3p promotes the myogenic differentiation of fetal bovine PDGFR&alpha progenitor cells. The expression of bta-miR-24-3p increased during myogenic differentiation. Overexpression of bta-miR-24-3p significantly promoted myogenic differentiation, but inhibited proliferation. A dual-luciferase assay identified ACVR1B as a direct target of bta-miR-24-3p. Similarly, knocking down ACVR1B by RNA interference also significantly inhibited proliferation and promoted the differentiation of bovine PDGFR&alpha progenitor cells. Thus, our study provides a mechanism in which bta-miR-24-3p regulates myogenesis by inhibiting ACVR1B expression. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-2615 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaba55d8ec118a6b338df0ca6530ef4 https://www.mdpi.com/2076-2615/9/11/859 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fbaba55d8ec118a6b338df0ca6530ef4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20762615 |
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