Lack of Association between Lactotransferrin Polymorphism and Dental Caries
| العنوان: | Lack of Association between Lactotransferrin Polymorphism and Dental Caries |
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| المؤلفون: | Tereza Trefná, Lubomír Kukla, P. Borilova Linhartova, Kristína Musilová, Martina Kukletová, L. Izakovicova Holla, J. Vlazny, Michaela Volčková |
| المصدر: | Caries Research. 48:39-44 |
| بيانات النشر: | S. Karger AG, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Guanine, Adolescent, Genotype, Dental Caries Susceptibility, Dentistry, Dental Caries, Arginine, Cohort Studies, Gene Frequency, Humans, Medicine, Dental Calculus, Child, General Dentistry, Czech Republic, 2. Zero hunger, Gynecology, Polymorphism, Genetic, DMF Index, business.industry, Adenine, Lysine, Dental Plaque Index, Exons, Lactotransferrin, Lactoferrin, Case-Control Studies, Female, Periodontal Index, business |
| الوصف: | Objective: Dental caries is a complex, multifactorial disease and one of the most common illnesses worldwide. Its etiology is related to microbial, dietary and host factors. Recent evidence suggests a role of lactotransferrin (LTF) in caries. The purpose of this study was to determine the association between LTF gene polymorphism and dental caries. Methods: In this case-control study, 637 unrelated children, aged 11-13 years, were enrolled. The subjects were divided into two groups, i.e. caries-free (decayed/missing/filled teeth = 0) and caries-affected children (decayed/missing/filled teeth ≥ 1). The LTF rs1126478 (140A/G in exon 2, Lys/Arg) genotypes were determined by PCR with restriction analysis using the EarI enzyme. Results: Of 637 children, 155 (24.3%) were caries free. There were no statistically significant differences between caries levels and allele or genotype distributions in the total cohort. When the caries-affected group (n = 482) was stratified into low (decayed/missing/filled teeth = 1), moderate (2 ≤ decayed/missing/filled teeth ≤ 3) and high (decayed/missing/filled teeth ≥ 4) caries experience, allele and genotype frequencies were similar among all subgroups. Conclusions: The LTF 140A/G (exon 2, Lys/Arg) polymorphism was not associated with the susceptibility to or severity of dental caries in the Czech population. |
| تدمد: | 1421-976X 0008-6568 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc4cc9fe5d6172c24ce5673d8d82cb9 https://doi.org/10.1159/000351689 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....fbc4cc9fe5d6172c24ce5673d8d82cb9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1421976X 00086568 |
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