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Towards MR-guided electron therapy: Measurement and simulation of clinical electron beams in magnetic fields

التفاصيل البيبلوغرافية
العنوان: Towards MR-guided electron therapy: Measurement and simulation of clinical electron beams in magnetic fields
المؤلفون: Marco Stampanoni, Paul J. Keall, Natalia Roberts, R. Kueng, Trent Causer, Bradley M Oborn, Peter Manser, Michael K. Fix
المصدر: Kueng, R.; Oborn, B. M.; Roberts, N. F.; Causer, T.; Stampanoni, M. F. M.; Manser, P.; Keall, P. J.; Fix, M. K. (2020). Towards MR-guided electron therapy: Measurement and simulation of clinical electron beams in magnetic fields. Physica medica, 78, pp. 83-92. Elsevier 10.1016/j.ejmp.2020.09.001 <http://dx.doi.org/10.1016/j.ejmp.2020.09.001>
Physica Medica, 78
بيانات النشر: ETH Zurich, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Electron therapy, medicine.medical_treatment, Monte Carlo method, Physics::Medical Physics, Biophysics, General Physics and Astronomy, Electrons, 610 Medicine & health, Electron, Linear particle accelerator, Imaging phantom, Collimated light, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Optics, medicine, Magnetic fields, MRI-linac, Monte Carlo, Radiology, Nuclear Medicine and imaging, Physics, business.industry, General Medicine, Magnetic Resonance Imaging, 030220 oncology & carcinogenesis, Cathode ray, Physics::Accelerator Physics, Particle Accelerators, business, Monte Carlo Method, Beam (structure)
الوصف: Purpose: In the current era of MRI-linac radiotherapy, dose optimization with arbitrary dose distributions is a reality. For the first time, we present new and targeted experiments and modeling to aid in evaluating the potential dose improvements offered with an electron beam mode during MRI-linac radiotherapy. Methods: Small collimated (1 cm diameter and 1.5 × 1.5 cm2 square) electron beams (6, 12 and 20 MeV) from a clinical linear accelerator (Varian Clinac 2100C) are incident perpendicular and parallel to the strong and localized magnetic fields (0–0.7 T) generated by a permanent magnet device. Gafchromic EBT3 film is placed inside a slab phantom to measure two-dimensional dose distributions. A benchmarked and comprehensive Monte Carlo model (Geant4) is established to directly compare with experiments. Results: With perpendicular fields a 5% narrowing of the beam FWHM and a 10 mm reduction in the 15% isodose penetration is seen for the 20 MeV beam. In the inline setup the penumbral width is reduced by up to 20%, and a local central dose enhancement of 100% is observed. Monte Carlo simulations are in agreement with the measured dose distributions (2% or 2 mm). Conclusion: A new range of experiments have been performed to offer insight into how an electron beam mode could offer additional choices in MRI-linac radiotherapy. The work extends on historic studies to bring a successful unified experimental and Monte Carlo modeling approach for studying small field electron beam dosimetry inside magnetic fields. The results suggest further work, particularly on the inline magnetic field scenario. © 2020 Associazione Italiana di Fisica Medica
Physica Medica, 78
ISSN:1120-1797
ISSN:1724-191X
وصف الملف: application/pdf; application/application/pdf
اللغة: English
تدمد: 1120-1797
1724-191X
DOI: 10.3929/ethz-b-000441497
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd408caeffe5451663aa14d5dee6fcd
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....fbd408caeffe5451663aa14d5dee6fcd
قاعدة البيانات: OpenAIRE
الوصف
تدمد:11201797
1724191X
DOI:10.3929/ethz-b-000441497