SARS-CoV-2 Infection and Racial Disparities in Children: Protective Mechanisms and Severe Complications Related to MIS-C
| العنوان: | SARS-CoV-2 Infection and Racial Disparities in Children: Protective Mechanisms and Severe Complications Related to MIS-C |
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| المؤلفون: | Sanjana Kurup, Fatou Tine, Dexter L. Lee, Ann Chahroudi, Regan Burgess |
| المصدر: | Journal of Racial and Ethnic Health Disparities |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Pediatrics, Health (social science), Sociology and Political Science, Population, MIS-C, Article, 03 medical and health sciences, 0302 clinical medicine, Immunity, 030225 pediatrics, Epidemiology, Pandemic, medicine, Humans, Kawasaki Disease, Child, education, Pandemics, education.field_of_study, SARS-CoV-2, business.industry, Health Policy, Public Health, Environmental and Occupational Health, COVID-19, medicine.disease, Systemic Inflammatory Response Syndrome, Health equity, Vaccination, 030104 developmental biology, Anthropology, Kawasaki disease, Health disparities, Complication, business |
| الوصف: | A novel coronavirus has resulted in a pandemic with over 176 million confirmed cases and over 3.8 million recorded deaths. In the USA, SARS-CoV-2 infection has a significant burden on minority communities, especially Hispanic and Black communities, which are overrepresented in cases compared to their percentage in the population. SARS-CoV-2 infection can manifest differently in children and adults, with children tending to have less severe disease. A review of current literature was performed to identify the hypothesized protective immune mechanisms in children, and to describe the rare complication of multisystem inflammatory syndrome in children (MIS-C) that has been documented in children post-SARS-CoV-2 infection. Epidemiologic data and case studies have indicated that children are less susceptible to more severe clinical features of SARS-CoV-2 infection, a finding that may be due to differences in the cytokine response generated by the innate immune system, high amounts of ACE-2 which maintain homeostatic functions by preventing inflammation, and trained immunity acquired from regular vaccinations. Despite these protective mechanisms, children are still susceptible to severe complications, such as MIS-C. The racial disparities seen in MIS-C are extremely apparent, and certain populations are more affected. Most specifically, 33% of MIS-C patients are Hispanic/Latino, and 30% Black. Current studies published on MIS-C do not detail whether certain symptoms are more present in certain racial/ethnic groups. Knowledge of these disparities could assist health care professionals with devising appropriate strategies for post-acute SARS-CoV-2 infection follow-up in children as well as vaccine distribution in specific communities to help slow the spread of SARS-CoV-2 infection, and ultimately reduce the potential for complications such as MIS-C. |
| تدمد: | 2196-8837 2197-3792 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc659869435db60cc4eeff42237d4467 https://doi.org/10.1007/s40615-021-01092-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fc659869435db60cc4eeff42237d4467 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 21968837 21973792 |
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