Gelatin methacrylate hydrogel with drug-loaded polymer microspheres as a new bioink for 3D bioprinting
| العنوان: | Gelatin methacrylate hydrogel with drug-loaded polymer microspheres as a new bioink for 3D bioprinting |
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| المؤلفون: | Adam Mirek, Habib Belaid, Aleksandra Bartkowiak, Fanny Barranger, Fanny Salmeron, Marilyn Kajdan, Marcin Grzeczkowicz, Vincent Cavaillès, Dorota Lewińska, Mikhael Bechelany |
| المساهمون: | Nalecz Institute of Biocybernetics and Biomedical Engineering (IBIB), Institut Européen des membranes (IEM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Gulf University for Science and Technology (GUST) |
| المصدر: | Biomaterials Advances Biomaterials Advances, 2023, 150, pp.213436. ⟨10.1016/j.bioadv.2023.213436⟩ |
| بيانات النشر: | HAL CCSD, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biomaterials, 3D bioprinting, Bioink, Drug delivery, Biomedical Engineering, [CHIM]Chemical Sciences, Bioengineering, Gelatin methacrylate, Microspheres, Cross-linking |
| الوصف: | International audience; 3D bioprinted hydrogel constructs are advanced systems of a great drug delivery application potential. One of the bioinks that has recently gained a lot of attention is gelatin methacrylate (GelMA) hydrogel exhibiting specific properties, including UV cross-linking possibility. The present study aimed to develop a new bioink composed of GelMA and gelatin modified by addition of polymer (polycaprolactone or polyethersulfone) microspheres serving as bioactive substance carriers. The prepared microspheres suspension in GelMA/gelatin bioink was successfully bioprinted and subjected to various tests, which showed that the addition of microspheres and their type affects the physicochemical properties of the printouts. The hydrogel stability and structure was examined using scanning electron and optical microscopy, its thermal properties with differential scanning calorimetry and thermogravimetric analysis and its biocompatibility on HaCaT cells using viability assay and electron microscopy. Analyses also included tests of hydrogel equilibrium swelling ratio and release of marker substance. Subsequently, the matrices were loaded with ampicillin and the antibiotic release was validated by monitoring the antibacterial activity on Staphylococcus aureus and Escherichia coli. It was concluded that GelMA/gelatin bioink is a good and satisfying material for potential medical use. Depending on the polymer used, the addition of microspheres improves its structure, thermal and drug delivery properties. |
| اللغة: | English |
| تدمد: | 2772-9516 2772-9508 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9642cb1b1e4f4afcef0948d6fc89f2 https://hal.umontpellier.fr/hal-04093481/document |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....fc9642cb1b1e4f4afcef0948d6fc89f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 27729516 27729508 |
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