Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides
| العنوان: | Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides |
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| المؤلفون: | Weidong Yong, Le Qing Qu, Dandan Qian, Fumio Takaiwa, Bin Qiu, Nan Zhou |
| المصدر: | Journal of Agricultural and Food Chemistry. 68:7162-7168 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Dose, Blood Pressure, Pharmacology, Rats, Inbred WKY, Intragastric administration, Rats, Inbred SHR, Animals, Medicine, cardiovascular diseases, Antihypertensive Agents, Plant Extracts, business.industry, Food protein, food and beverages, Oryza, General Chemistry, Plants, Genetically Modified, Genetically modified rice, Rats, Wistar kyoto, Blood pressure, Hypertension, Seeds, Peptides, General Agricultural and Biological Sciences, business, Serum chemistry |
| الوصف: | Peptides derived from food protein have the potential to become antihypertensive agents with relatively few negative side effects. Herein, multiple antihypertensive peptides, extracted from the transgenic rice seed, were administered intragastrically into spontaneously hypertensive rats (SHRs) with different dosages, resulting in a significant decrease in the systolic blood pressure (SBP). Furthermore, for a period of 5 weeks, daily intragastric administration of the transgenic rice flour also significantly reduced the SBP of SHRs but not the Wistar Kyoto normotensive rats (WNRs), most importantly, which did not affect the growth, development, or serum chemistry of SHRs or WNRs and did not cause any pathological changes. Our work provides an alternative source of natural antihypertensive agents. |
| تدمد: | 1520-5118 0021-8561 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbd0b53d67aadff993fc7753f95b3c3 https://doi.org/10.1021/acs.jafc.0c01958 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....fcbd0b53d67aadff993fc7753f95b3c3 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205118 00218561 |
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