Capsaicin cough sensitivity decreases with successful treatment of chronic cough
| العنوان: | Capsaicin cough sensitivity decreases with successful treatment of chronic cough |
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| المؤلفون: | Neil B. Pride, F O'Connell, V.E. Thomas, R W Fuller |
| المصدر: | American Journal of Respiratory and Critical Care Medicine. 150:374-380 |
| بيانات النشر: | American Thoracic Society, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Adult, Male, Pulmonary and Respiratory Medicine, Visual analogue scale, Provocation test, Angiotensin-Converting Enzyme Inhibitors, Critical Care and Intensive Care Medicine, Subgroup B, Treatment failure, chemistry.chemical_compound, medicine, Humans, Aged, Rhinitis, Aged, 80 and over, business.industry, Respiratory disease, Middle Aged, medicine.disease, Histamine Challenge Test, respiratory tract diseases, Chronic cough, Cough, chemistry, Capsaicin, Anesthesia, Chronic Disease, Gastroesophageal Reflux, Female, medicine.symptom, business |
| الوصف: | To assess the role of enhanced cough sensitivity in the pathogenesis of cough, we measured cough severity on a visual analogue scale (VAS) and capsaicin cough sensitivity (the concentration required to elicit two [C2] and five [C5] coughs) in 87 consecutive patients referred with chronic cough. Measurements were repeated after complete investigation and treatment, when patients were entered into one of four study groups: (1) treatment success (primary cause of cough successfully treated with elimination of the cough, n = 48); (2) primary treatment failure (treatment of potential primary cause of cough unsuccessful, n = 12); (3) cough treatment failure subgroup A (potential primary cause of cough identified and successfully treated but no improvement in cough, n = 8); and (4) cough treatment failure subgroup B (no potential primary cause of cough identified, n = 19). All patients in groups 3 and 4 were nonsmokers, had normal chest radiography and negative histamine challenge test, and failed to respond to intensive empirical treatment for rhinitis and gastroesophageal reflux. The VAS cough severity was lower and log C2 and C5 higher after treatment compared with initial values in the treatment success group but not in the other three groups. Enhanced sensitivity of airway nerves that mediate cough is important in the pathogenesis of nonproductive cough, and successful treatment is associated with a reduction in cough sensitivity. While enhanced sensitivity of airway nerves is usually present in patients with identifiable causes of chronic nonproductive cough, it is also found in other patients in whom the cause of cough is unknown. |
| تدمد: | 1535-4970 1073-449X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc5d453ad5c78f4ae8ae62255da51a7 https://doi.org/10.1164/ajrccm.150.2.8049818 |
| رقم الأكسشن: | edsair.doi.dedup.....fcc5d453ad5c78f4ae8ae62255da51a7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354970 1073449X |
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