Clinical validation and comparison of the Comprehensive Complication Index and Clavien-Dindo classification in predicting post-operative outcomes after cytoreductive surgery in advanced ovarian cancer
| العنوان: | Clinical validation and comparison of the Comprehensive Complication Index and Clavien-Dindo classification in predicting post-operative outcomes after cytoreductive surgery in advanced ovarian cancer |
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| المؤلفون: | Malika Kengsakul, Gatske M Nieuwenhuyzen-de Boer, Suwasin Udomkarnjananun, Stephen J Kerr, Helena C van Doorn, Heleen J van Beekhuizen |
| المساهمون: | Gynecological Oncology |
| المصدر: | International Journal of Gynecological Cancer, 33(2), 263-270. BMJ Publishing Group |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Oncology, SDG 3 - Good Health and Well-being, Obstetrics and Gynecology |
| الوصف: | ObjectiveThe Comprehensive Complication Index (CCI) is an instrument used to measure cumulative post-operative complications. Our study aimed to validate the CCI after cytoreductive surgery for primary advanced-stage epithelial ovarian cancer, and to compare its diagnostic performance with the Clavien-Dindo classification.MethodsThis prospective cohort study classified post-operative complications according to the Clavien-Dindo classification and the CCI. Logistic regression was used to determine the association between both classifications with intensive care unit admission, prolonged length of hospital stay (defined as stays longer than the 75th percentile of all stays in this study), 30-day readmission, and time to initiating chemotherapy after surgery >42 days. Area under the receiver operating characteristic curves (AUC) were used to assess the discriminative performance of each classification.ResultsA total of 300 patients were included in the analysis. Most patients (n=255, 85%) underwent interval cytoreductive surgery. Complete cytoreduction was achieved in 235 (78%) patients. Overall, 30-day post-operative complications classified by the Clavien-Dindo classification occurred in 147 (49%) patients. Severe complications (grade ≥3a) occurred in 51 (17%) patients. Approximately 30% (n=82) had multiple complications. The CCI showed an excellent correlation with the Clavien-Dindo classification (r=0.906, p42 days (all pConclusionsBoth the Clavien-Dindo classification and CCI showed significant associations with all surgical outcomes. However, the cumulative complications score of the CCI demonstrated a more superior discriminative performance than the Clavien-Dindo classification for prolonged length of hospital stay in advanced-stage epithelial ovarian cancer. |
| تدمد: | 1525-1438 1048-891X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf535ae985ec119a647bc6572abccc2 https://pubmed.ncbi.nlm.nih.gov/36600504 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....fcf535ae985ec119a647bc6572abccc2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15251438 1048891X |
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