Concussive Brain Trauma in the Mouse Results in Acute Cognitive Deficits and Sustained Impairment of Axonal Function
| العنوان: | Concussive Brain Trauma in the Mouse Results in Acute Cognitive Deficits and Sustained Impairment of Axonal Function |
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| المؤلفون: | Jennifer A Creed, Alan Tessler, Douglas Paul Fox, Ann Mae DiLeonardi, Ramesh Raghupathi |
| المصدر: | Journal of Neurotrauma. 28:547-563 |
| بيانات النشر: | Mary Ann Liebert Inc, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Traumatic brain injury, Blotting, Western, Action Potentials, Poison control, Hippocampus, Axonal Transport, Mice, Cognition, Cortex (anatomy), Concussion, medicine, Animals, Maze Learning, Brain Concussion, Neurons, Analysis of Variance, Dentate gyrus, Original Articles, medicine.disease, Axons, Memory, Short-Term, medicine.anatomical_structure, nervous system, Anesthesia, Nerve Degeneration, Closed head injury, Neurology (clinical), Righting reflex, Cognition Disorders, Psychology |
| الوصف: | Concussive brain injury (CBI) accounts for approximately 75% of all brain-injured people in the United States each year and is particularly prevalent in contact sports. Concussion is the mildest form of diffuse traumatic brain injury (TBI) and results in transient cognitive dysfunction, the neuropathologic basis for which is traumatic axonal injury (TAI). To evaluate the structural and functional changes associated with concussion-induced cognitive deficits, adult mice were subjected to an impact on the intact skull over the midline suture that resulted in a brief apneic period and loss of the righting reflex. Closed head injury also resulted in an increase in the wet weight:dry weight ratio in the cortex suggestive of edema in the first 24 h, and the appearance of Fluoro-Jade-B-labeled degenerating neurons in the cortex and dentate gyrus of the hippocampus within the first 3 days post-injury. Compared to sham-injured mice, brain-injured mice exhibited significant deficits in spatial acquisition and working memory as measured using the Morris water maze over the first 3 days (p |
| تدمد: | 1557-9042 0897-7151 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1d2954d9ba5e49383ebab868203426 https://doi.org/10.1089/neu.2010.1729 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fd1d2954d9ba5e49383ebab868203426 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15579042 08977151 |
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