Effects of PEP-1-FK506BP on cyst formation in polycystic kidney disease
| العنوان: | Effects of PEP-1-FK506BP on cyst formation in polycystic kidney disease |
|---|---|
| المؤلفون: | Hyo Sang Jo, Won Sik Eum, Eun Young Park, Je Young Ko, Do Yeon Kim, Dae Won Kim, Min Jea Shin, Ora Son, Su Bin Cho, Jung Hwan Park, Chi Hern Lee, Eun Ji Yeo, Hyeon Ji Yeo, Yeon Joo Choi, Jong Kyu Youn, Sung-Woo Cho, Jinseu Park, Jong Hoon Park, Soo Young Choi |
| المصدر: | BMB REPORTS(50): 9 BMB Reports |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 3D culture, 0301 basic medicine, medicine.medical_specialty, education, Protein therapy, Biochemistry, 03 medical and health sciences, Internal medicine, Cyst formation, PEP-1-FK506BP, Polycystic kidney diseases, Proteintherapy, medicine, Polycystic kidney disease, Molecular Biology, Therapeutic strategy, Kidney, 030102 biochemistry & molecular biology, Cell growth, Chemistry, Articles, General Medicine, medicine.disease, Blot, FKBP, Endocrinology, medicine.anatomical_structure, cardiovascular system, Cell signaling pathways |
| الوصف: | Polycystic kidney disease (PKD) is one of the most common inherited disorders, involving progressive cyst formation in the kidney that leads to renal failure. FK506 binding protein 12 (FK506BP) is an immunophilin protein that performs multiple functions, including regulation of cell signaling pathways and survival. In this study, we determined the roles of PEP-1-FK506BP on cell proliferation and cyst formation in PKD cells. Purified PEP-1-FK506BP transduced into PKD cells markedly inhibited cell proliferation. Also, PEP-1-FK506BP drastically inhibited the expression levels of p-Akt, p-p70S6K, p-mTOR, and p-ERK in PKD cells. In a 3D-culture system, PEP-1-FK506BP significantly reduced cyst formation. Furthermore, the combined effects of rapamycin and PEP-1-FK506BP on cyst formation were markedly higher than the effects of individual treatments. These results suggest that PEP-1-FK506BP delayed cyst formation and could be a new therapeutic strategy for renal cyst formation in PKD. [BMB Reports 2017; 50(9): 460-465]. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5ebaefda4a929a3f91d507eb653ed6 http://open-repository.kisti.re.kr/cube/handle/open_repository/477986.do |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fd5ebaefda4a929a3f91d507eb653ed6 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |