A common epitope between HLA-B27, -B13 and -B37 alloantigens defined by a monoclonal antibody
| العنوان: | A common epitope between HLA-B27, -B13 and -B37 alloantigens defined by a monoclonal antibody |
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| المؤلفون: | Renée Fauchet, Dominique Bourel, O. Bouhallier, G. Merdrignac, Bernard Genetet, G. Dejour, G. Chales |
| المصدر: | Tissue Antigens. 30:97-103 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.drug_class, Immunology, Cell, Fluorescent Antibody Technique, Cross Reactions, Biology, Monoclonal antibody, Biochemistry, Peripheral blood mononuclear cell, Epitope, Epitopes, Antigen, HLA Antigens, Genetics, medicine, Humans, Immunology and Allergy, Cytotoxic T cell, HLA-B13 Antigen, HLA-B27 Antigen, HLA-B27, Antibodies, Monoclonal, General Medicine, Cytotoxicity Tests, Immunologic, Molecular biology, HLA-B37 Antigen, medicine.anatomical_structure, HLA-B Antigens, Reagent |
| الوصف: | An anti-HLA-B27 monoclonal antibody produced by the hybridoma technique is described. This BD.7 reagent is a cytotoxic IgM antibody. Its reactivity was studied by lymphocytotoxicity tests, indirect immunolfluorescence tests and biochemical analysis against an extensive panel of peripheral blood mononuclear cells. All HLA-B27 positive samples, either from normal subjects or from patients with Ankylosing Spondylitis, were recognized by this reagent. Moreover, a cross-reaction was observed with HLA-B13 cells, and a new unexpected reaction with all HLA-B37 cell suspensions. The interest of such a reagent is discussed. |
| تدمد: | 1399-0039 0001-2815 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd650ba273f0ff9a0ae206401749ef03 https://doi.org/10.1111/j.1399-0039.1987.tb01604.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....fd650ba273f0ff9a0ae206401749ef03 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13990039 00012815 |
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