Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance
| العنوان: | Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance |
|---|---|
| المؤلفون: | Beverley Robertson, Adam Davie, Stuart M. Haslam, Huan Cao, Wendy J Pickford, Heather M. Wilson, Robert N. Barker, Heather J. Wassall, Gordon D. Brown, Sadie Henderson, Anne Dell, Aristotelis Antonopoulos, Megan A Forrester, J. Alexandra Rowe, Bhinal Patel, Gabriela Konieczny, Mark A. Vickers, Dimitris Tampakis, Michael Moss, Lindsay S Hall, Maria-Louise Williams, Beverley E. Minter, David C. Rees, John N. Brewin, Lars Erwig, Charlotte S. Lennon, Jenna Shepherd, Alanna Masson |
| المصدر: | Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021) Nature Communications Cao, H, Antonopoulos, A, Henderson, S, Wassall, H, Brewin, J, Masson, A, Shepherd, J, Konieczny, G, Patel, B, Williams, M-L, Davie, A, Forrester, M A, Hall, L, Minter, B, Tampakis, D, Moss, M, Lennon, C, Pickford, W, Erwig, L, Robertson, B, Dell, A, Brown, G D, Wilson, H M, Rees, D C, Haslam, S M, Alexandra Rowe, J, Barker, R N & Vickers, M A 2021, ' Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance ', Nature Communications, vol. 12, no. 1, 1792 . https://doi.org/10.1038/s41467-021-21814 |
| بيانات النشر: | Nature Research, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Erythrocytes, Glycobiology, General Physics and Astronomy, Mannose, Ligands, chemistry.chemical_compound, 0302 clinical medicine, Spectrin, Malaria, Falciparum, Receptors, Immunologic, Phagocytes, Multidisciplinary, Membrane Glycoproteins, biology, Chemistry, Pattern recognition receptor, hemic and immune systems, Flow Cytometry, Hemolysis, 3. Good health, Multidisciplinary Sciences, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Science & Technology - Other Topics, Mannose receptor, Protein Binding, Pattern recognition receptors, Science, Plasmodium falciparum, Anemia, Sickle Cell, Article, General Biochemistry, Genetics and Molecular Biology, Microbiology, 03 medical and health sciences, Phagocytosis, Polysaccharides, medicine, Humans, Sickle cell trait, Science & Technology, Sickle cell disease, Erythrocyte Membrane, General Chemistry, medicine.disease, biology.organism_classification, Malaria, Red blood cell, 030104 developmental biology |
| الوصف: | In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans (Man5-9GlcNAc2), expressed on diseased or oxidized RBC surfaces, bind the mannose receptor (CD206) on phagocytes to mediate clearance. We find that extravascular hemolysis in sickle cell disease correlates with high mannose glycan levels on RBCs. Furthermore, Plasmodium falciparum-infected RBCs expose surface mannose N-glycans, which occur at significantly higher levels on infected RBCs from sickle cell trait subjects compared to those lacking hemoglobin S. The glycans are associated with high molecular weight complexes and protease-resistant, lower molecular weight fragments containing spectrin. Recognition of surface N-linked high mannose glycans as a response to cellular stress is a molecular mechanism common to both the pathogenesis of sickle cell disease and resistance to severe malaria in sickle cell trait. Red blood cells (RBCs) are phagocytosed in the spleen in sickle cell disease and malaria. Here, Cao et al. show that high mannose N-glycans, exposed on diseased or oxidized RBC surfaces, bind mannose receptor CD206 on host cells, mediating phagocytosis. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd89a3aee2973519b6303389fca5a20d http://hdl.handle.net/10044/1/89825 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fd89a3aee2973519b6303389fca5a20d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |