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Early natural killer cell counts in blood predict mortality in severe sepsis

التفاصيل البيبلوغرافية
العنوان: Early natural killer cell counts in blood predict mortality in severe sepsis
المؤلفون: David Andaluz-Ojeda, José María Eiros, Rosa Diego, Raúl Ortiz de Lejarazu, Verónica Iglesias, Francisco Gandía, Concepción Nieto, Lucia Rico, Salvador Resino, Felipe Bobillo, Eduardo Tamayo, E. Ramos, Ana Ma Loma, Raquel Almansa, Mercedes Nocito, Jesus F. Bermejo-Martin
المصدر: Scopus-Elsevier
UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname
Critical Care
بيانات النشر: Springer Science and Business Media LLC, 2011.
سنة النشر: 2011
مصطلحات موضوعية: Male, Critical Care and Intensive Care Medicine, Septicemia - Mortalidad, Natural killer cell, Sepsis, Immune system, T-Lymphocyte Subsets, medicine, Humans, Hospital Mortality, Survival analysis, biology, Septic shock, business.industry, Research, medicine.disease, Shock, Septic, Killer Cells, Natural, Intensive Care Units, medicine.anatomical_structure, Immunology, biology.protein, Female, Immunocompetence, Antibody, business, CD8
الوصف: Producción Científica
In an attempt to evaluate the quantitative changes in the status of immunocompetence in severe sepsis over time and its potential influence on clinical outcome, we monitored the evolution of immunoglobulins (Igs) (IgG, IgA and IgM), complement factors (C3 and C4) and lymphocyte subsets (CD4+ T cells, CD8+ T cells, B cells (CD19+) and natural killer (NK) cells (CD3-CD16+CD56+)) in the blood of 50 patients with severe sepsis or septic shock at day 1, day 3 and day 10 following admission to the ICU. Twenty-one patients died, ten of whom died within the 72 hours following admission to the ICU. The most frequent cause of death (n = 12) was multiorgan dysfunction syndrome. At day 1, survivors showed significantly higher levels of IgG and C4 than those who ultimately died. On the contrary, NK cell levels were significantly higher in the patients who died. Survivors exhibited a progressive increase from day 1 to day 10 on most of the immunological parameters evaluated (IgG, IgA, IgM, C3, CD4+, CD8+ T cells and NK cells). Multivariate Cox regression analysis, including age, sex, APACHE II score, severe sepsis or septic shock status and each one of the immunological parameters showed that NK cell counts at day 1 were independently associated with increased risk of death at 28 days (hazard ratio = 3.34, 95% CI = 1.29 to 8.64; P = 0.013). Analysis of survival curves provided evidence that levels of NK cells at day 1 (> 83 cells/mm3) were associated with early mortality. Our results demonstrate the prognostic role of NK cells in severe sepsis and provide evidence for a direct association of early counts of these cells in blood with mortality.
وصف الملف: application/pdf
تدمد: 1364-8535
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8abdeb54fe18243b8e2a5552caa9ae
https://doi.org/10.1186/cc10501
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....fd8abdeb54fe18243b8e2a5552caa9ae
قاعدة البيانات: OpenAIRE
الوصف
تدمد:13648535