Paracoccidioidomycosis in Immunocompromised Patients: A Literature Review
| العنوان: | Paracoccidioidomycosis in Immunocompromised Patients: A Literature Review |
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| المؤلفون: | Arnaldo Lopes Colombo, João Nobrega de Almeida, Paula M Peçanha-Pietrobom |
| المصدر: | Journal of Fungi Journal of Fungi, Vol 5, Iss 1, p 2 (2018) |
| بيانات النشر: | MDPI, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), kidney transplant, Pediatrics, medicine.medical_specialty, animal structures, literature review, 030106 microbiology, Population, lymphoma, Plant Science, Review, TNF inhibitors, 03 medical and health sciences, paracoccidioidomycosis, medicine, Carcinoma, cancer, education, skin and connective tissue diseases, lcsh:QH301-705.5, Ecology, Evolution, Behavior and Systematics, Kidney transplantation, education.field_of_study, business.industry, Paracoccidioidomycosis, urogenital system, Mortality rate, Cancer, HIV, medicine.disease, Lymphoma, Natural history, lcsh:Biology (General), embryonic structures, business |
| الوصف: | Paracoccidioidomycosis (PCM) is an endemic mycosis found in Latin America that causes systemic disease mostly in immunocompetent hosts. A small percentage of PCM occurs in immunocompromised patients where low clinical suspicion of the infection, late diagnosis, and uncertainties about its management are factors that negatively impact their outcomes. We conducted a literature review searching reports on PCM associated to HIV, cancer, maligned hemopathies, solid organ transplantation, and immunotherapies, in order to check for peculiarities in terms of natural history and challenges in the clinical management of PCM in this population. HIV patients with PCM usually had low T CD4+ cell counts, pulmonary and lymph nodes involvement, and a poorer prognosis (≈50% mortality). Most of the patients with PCM and cancer had carcinoma of the respiratory tract. Among maligned hemopathies, PCM was more often related to lymphoma. In general, PCM prognosis in patients with malignant diseases was related to the cancer stage. PCM in transplant recipients was mostly associated with the late phase of kidney transplantation, with a high mortality rate (44%). Despite being uncommon, reactivation of latent PCM may take place in the setting of immunocompromised patients exhibiting clinical particularities and it carries higher mortality rates than normal hosts. |
| اللغة: | English |
| تدمد: | 2309-608X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd35b04e3eee966b40cd4e4e9e36403 http://europepmc.org/articles/PMC6463037 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fdd35b04e3eee966b40cd4e4e9e36403 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2309608X |
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