The vascular endothelial growth factor signaling pathway regulates liver sinusoidal endothelial cells during liver regeneration after partial hepatectomy
| العنوان: | The vascular endothelial growth factor signaling pathway regulates liver sinusoidal endothelial cells during liver regeneration after partial hepatectomy |
|---|---|
| المؤلفون: | Xiaoqian Zhang, Ya-Lei Zhao, Juan Lu, Lanjuan Li |
| المصدر: | Expert Review of Gastroenterology & Hepatology. 15:139-147 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Partial hepatectomy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Animals, Hepatectomy, Humans, Medicine, Cell Proliferation, Hepatology, Vascular Endothelial Growth Factors, business.industry, Liver cell, Gastroenterology, Endothelial Cells, Liver regeneration, Liver Regeneration, Cell biology, Vascular endothelial growth factor, Phenotype, chemistry, 030220 oncology & carcinogenesis, Hepatocytes, 030211 gastroenterology & hepatology, Signal transduction, Fenestration, business, Signal Transduction |
| الوصف: | Liver regeneration after partial hepatectomy is a very complex and well-regulated procedure. It utilizes all liver cell types, which are associated with signaling pathways involving growth factors, cytokines, and stimulatory and inhibitory feedback of several growth-related signals. Liver sinusoidal endothelial cells (LSECs) contribute to liver regeneration after partial hepatectomy. Vascular endothelial growth factor (VEGF) has various functions in LSECs. In this review, we summarize the relationship between VEGF and LSECs involving VEGF regulatory activity in the vascular endothelium.Maintenance of the fenestrated LSEC phenotype requires two VEGF pathways: VEGF stimulated-NO acting through the cGMP pathway and VEGF independent of nitric oxide (NO). The results suggest that VEGF is a key regenerating mediator of LSECs in the partial hepatectomy model. NO-independent pathway was also essential to the maintenance of the LSEC in liver regeneration.Liver regeneration remains a fascinating and significative research field in recent years. The liver involved of molecular pathways except for LSEC-VEGF pathways that make the field of liver further depth studies should be put into effect to elaborate the undetermined confusions, which will be better to understand liver regeneration. |
| تدمد: | 1747-4132 1747-4124 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdea3ce970d7680f33dc5bce79b4a25b https://doi.org/10.1080/17474124.2020.1815532 |
| رقم الأكسشن: | edsair.doi.dedup.....fdea3ce970d7680f33dc5bce79b4a25b |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17474132 17474124 |
|---|