Heart‑lung crosstalk in pulmonary arterial hypertension following myocardial infarction (Review)
| العنوان: | Heart‑lung crosstalk in pulmonary arterial hypertension following myocardial infarction (Review) |
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| المؤلفون: | Haixu Guo, Jinrong Xu, Hui Luo, Xiaorong Shui, Yuan He, Huang Shi'an, Shuyun Cai, Wenfeng Ye, Wei Lei |
| المصدر: | International Journal of Molecular Medicine |
| بيانات النشر: | Spandidos Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Exacerbation, vascular endothelial cells, interaction, cardiomyocyte, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Genetics, medicine, Animals, Humans, Myocyte, Myocytes, Cardiac, Myocardial infarction, Lung, Pathological, Pulmonary Arterial Hypertension, Ischemic cardiomyopathy, business.industry, Articles, General Medicine, medicine.disease, Pathophysiology, myocardial infarction, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Heart failure, Cardiology, business |
| الوصف: | Left heart disease is the main cause of clinical pulmonary arterial hypertension (PAH). Common types of left heart disease that result in PAH include heart failure, left ventricular systolic dysfunction, left ventricular diastolic dysfunction and valvular disease. It is currently believed that mechanical pressure caused by high pulmonary venous pressure is the main cause of myocardial infarction (MI) in individuals with ischemic cardiomyopathy and left ventricular systolic dysfunction. In the presence of decreased cardiac function, vascular remodeling of pulmonary vessels in response to long‑term stimulation by high pressure in turn leads to exacerbation of PAH. However, the underlying pathological mechanisms remain unclear. Elucidating the association between the development of MI and PAH may lead to a better understanding of potential risk factors and better disease treatment. In this article, the pathophysiological effects of multiple systems in individuals with MI and PAH were reviewed in order to provide a general perspective on various potential interactions between cardiomyocytes and pulmonary vascular cells. |
| تدمد: | 1791-244X 1107-3756 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe26050d6533009a9c096b1e29e910b9 https://doi.org/10.3892/ijmm.2020.4650 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fe26050d6533009a9c096b1e29e910b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1791244X 11073756 |
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