Hypertriglyceridemia associated with Tumor Necrosis Factor-α in Hamster Cheek-pouch Carcinogenesis
| العنوان: | Hypertriglyceridemia associated with Tumor Necrosis Factor-α in Hamster Cheek-pouch Carcinogenesis |
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| المؤلفون: | Toshitaka Kage, M. Harada, Takehiro Chino, Junko Nakajima, Makio Mogi |
| المصدر: | Journal of Dental Research. 74:1558-1563 |
| بيانات النشر: | SAGE Publications, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, 9,10-Dimethyl-1,2-benzanthracene, Blotting, Western, DMBA, Biology, Cachexia, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Cheek pouch, Cricetinae, Internal medicine, medicine, Animals, Humans, General Dentistry, Triglycerides, Hypertriglyceridemia, Lipoprotein lipase, Mesocricetus, Triglyceride, Tumor Necrosis Factor-alpha, digestive, oral, and skin physiology, nutritional and metabolic diseases, 030206 dentistry, medicine.disease, Recombinant Proteins, Disease Models, Animal, Lipoprotein Lipase, Cheek, 030104 developmental biology, Endocrinology, chemistry, Carcinogens, Carcinoma, Squamous Cell, Mouth Neoplasms, lipids (amino acids, peptides, and proteins), Tumor necrosis factor alpha |
| الوصف: | We demonstrated for the first time that 9,10-dimethyl-1,2-benzanthracene (DMBA)-treated hamsters showed hypertriglyceridemia followed by cachexia. Hypertriglyceridemia is believed to be caused in part by the decreased lipoprotein lipase (LPL) activity, and by cytokines such as tumor necrosis factor (TNF)-alpha. In addition, TNF-alpha action is associated with the LPL activity. Therefore, we determined the content of triglyceride (TG), LPL, and TNF-alpha in the serum from DMBA-treated hamsters. Elevated TG concentration in the serum of tumor-bearing hamsters was more remarkable and preceded the increase in other lipids, whereas the activity of LPL, the key enzyme of TG metabolism in vivo, was drastically reduced. TNF-alpha, known as an endogenous inhibitor of LPL activity, was detected in both the sera and the extract of tumors from DMBA-treated hamsters, whereas it was not detectable in any control samples. Pre-incubation of control sera with exogenous recombinant human TNF-alpha resulted in a potent inhibition of endogenous LPL activity in a dose-dependent manner in vitro. Therefore, the presence of TNF-alpha might lead to the increase in plasma TG mediated by LPL in tumor-bearing hamsters. |
| تدمد: | 1544-0591 0022-0345 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2c0e51bea90ebfe2ae49153d67bb9a https://doi.org/10.1177/00220345950740090901 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....fe2c0e51bea90ebfe2ae49153d67bb9a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15440591 00220345 |
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