New Synthetic Cathinones and Phenylethylamine Derivatives Analysis in Hair: A Review
| العنوان: | New Synthetic Cathinones and Phenylethylamine Derivatives Analysis in Hair: A Review |
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| المؤلفون: | Vittorio Bolcato, Matteo Moretti, Alessandra Radogna, Claudia Carelli, Francesca Freni, Luca Morini |
| المصدر: | Molecules Molecules, Vol 26, Iss 6143, p 6143 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Phenethylamine, Drugs of abuse, Methylone, Pharmaceutical Science, Organic chemistry, Review, NPS, Gas Chromatography-Mass Spectrometry, Analytical Chemistry, chemistry.chemical_compound, Forensic Toxicology, Mephedrone, QD241-441, Alkaloids, Limit of Detection, Tandem Mass Spectrometry, Drug Discovery, Phenethylamines, medicine, Humans, Physical and Theoretical Chemistry, Butylone, Chromatography, Illicit Drugs, synthetic cathinones, Hair analysis, Mass spectrometric, Substance Abuse Detection, phenylethylamine and derivatives, chemistry, Chemistry (miscellaneous), Molecular Medicine, hair analysis, Gas chromatography, medicine.drug, Chromatography, Liquid, Hair |
| الوصف: | The analysis of psychoactive substances in hair is of great importance for both clinical and forensic toxicologists since it allows one to evaluate past and continuative exposure to xenobiotics. In particular, a new challenge is represented by new psychoactive substances: Among this new class of drugs of abuse, synthetic cathinone and phenethylamine derivatives are often detected in biological samples. Hence, there is a growing need to develop new analytical procedures or improve old ones in order to conduct evaluations of these emerging substances. This study is a systematic review of all the instrumental and experimental data available in the literature. A total of 32 articles were included in the review. Acidic solvents proved to be the most reliable solutions for extraction. Gas chromatography and liquid chromatography coupled to tandem mass spectrometric and high-resolution mass spectrometric systems represent the majority of the involved instrumental techniques. Sensitivity must be maintained at the pg/mg level to detect any occurrences up to occasional consumption. In total, 23 out of 32 articles reported real positive samples. The most frequently detected substance in hair was mephedrone, followed by butylone, methylone, MDPV, and α-pyrrolidinophenone-type substances. |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3bffc1cad52ac0e906ef3e5a27865c https://pubmed.ncbi.nlm.nih.gov/34684725 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fe3bffc1cad52ac0e906ef3e5a27865c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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