Efficacy and safety of standard and low dose ticagrelor versus clopidogrel in east AsianPatients with chronic total occlusion undergoing percutaneous coronary intervention: a single center retrospective study
| العنوان: | Efficacy and safety of standard and low dose ticagrelor versus clopidogrel in east AsianPatients with chronic total occlusion undergoing percutaneous coronary intervention: a single center retrospective study |
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| المؤلفون: | Cheng-fu Wang, Xiao-jiao Zhang, Qing-kun Meng, Chun-sheng Cui, Yu Zhu, Hong-wei Zhao, De-feng Luo, Jie Tao, Yong Wang, Bo Luan, Ai-jie Hou |
| المصدر: | BMC Cardiovascular Disorders BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-8 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, China, Ticagrelor, Time Factors, medicine.medical_treatment, Hemorrhage, Single Center, Loading dose, Percutaneous coronary intervention, Asian People, Risk Factors, Internal medicine, medicine, Humans, cardiovascular diseases, Aged, Retrospective Studies, business.industry, Retrospective cohort study, Middle Aged, Clopidogrel, Cardiac surgery, Chronic total occlusion, Treatment Outcome, Coronary Occlusion, lcsh:RC666-701, Conventional PCI, Chronic Disease, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, medicine.drug, Research Article |
| الوصف: | Background Patients with coronary chronic total occlusion (CTO) require effective antiplatelet therapy after percutaneous coronary intervention (PCI). Ticagrelor has more pronounced platelet inhibition than clopidogrel. However, the most appropriate dose of ticagrelor in East Asian populations remains unclear. Method We compared ticagrelor (180 mg loading dose, 90 mg twice daily thereafter and 120 mg loading dose, 60 mg twice daily thereafter) and clopidogrel (300 mg loading dose, 75 mg daily thereafter) for prevention of cardiovascular events in 525patients with CTO undergoing PCI. Results The rate of in-hospital major adverse cardiac and cerebral events (MACCE) was not different between the groups. At 1-year follow-up, target vessel revascularization (TVR) in both ticagrelor groups were significantly lower than that in the clopidogrel group (p = 0.047); TVR was significantly decreased in 60 mg ticagrelor compared to standard dose clopidogrel (p = 0.046). At 1-year follow-up, overall MACCE in both ticagrelor groups were significantly lower than that in the clopidogrel group (p = 0.023). Kaplan–Meier analysis showed MACCE-free survival was significantly higher in both ticagrelor groups than in the clopidogrel group (p = 0.024). During hospitalization, minor bleeding was significant increased in the 90 mg ticagrelor group (p = 0.021). At 1-year follow-up, risk of major and minor bleeding were significantly increased in the 90 mg ticagrelor group. Conclusion In East Asian patients with CTO undergoing PCI, 60 mg ticagrelor was as effective as 90 mg, at the same time significantly reduced risk of bleeding. |
| تدمد: | 1471-2261 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe793b995f3c4d809bfa695cf37992af https://pubmed.ncbi.nlm.nih.gov/32138662 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....fe793b995f3c4d809bfa695cf37992af |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712261 |
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