Only peak thyroglobulin concentration on day 1 and 3 of rhTSH-aided RAI adjuvant treatment has prognostic implications in differentiated thyroid cancer
| العنوان: | Only peak thyroglobulin concentration on day 1 and 3 of rhTSH-aided RAI adjuvant treatment has prognostic implications in differentiated thyroid cancer |
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| المؤلفون: | Barbara Jarząb, Kornelia Hasse-Lazar, Daria Handkiewicz-Junak, Agnieszka Kotecka-Blicharz, Aneta Kluczewska-Gałka, Ewa Paliczka-Cieślik, Aleksandra Ledwon, Aleksandra Kropińska, Tomasz Olczyk, Aleksandra Sygula |
| المصدر: | Annals of Nuclear Medicine |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, Urology, Thyroid carcinoma, Prognostic marker, Recombinant human thyroid-stimulating hormone (rhTSH), Medicine, Radiology, Nuclear Medicine and imaging, Thyroid Neoplasms, Thyroid cancer, Fluorodeoxyglucose, Univariate analysis, medicine.diagnostic_test, business.industry, Radioiodine (RAI), Thyroid, Thyroidectomy, Magnetic resonance imaging, Structural recurrence, General Medicine, medicine.disease, medicine.anatomical_structure, Original Article, Thyroglobulin, Differentiated thyroid carcinoma (DTC), business, Thyroglobulin (Tg), medicine.drug |
| الوصف: | Objective In patients with differentiated thyroid carcinoma (DTC), serum thyroglobulin levels measured at the time of remnant ablation after thyroid hormone withdrawal were shown to have prognostic value for disease-free status. We sought to evaluate serial thyroglobulin measurements at the time of recombinant human thyroid-stimulating hormone (rhTSH)-aided iodine 131 (131I) adjuvant treatment as prognostic markers of DTC. Methods Six hundred-fifty patients with DTC given total/near-total thyroidectomy and adjuvant radioiodine post-rhTSH stimulation were evaluated. Thyroglobulin was measured on day 1 (Tg1; at the time of the first rhTSH injection), day 3 (Tg3; 1 day after the second, final rhTSH injection), and day 6 (Tg6; 3 days post-radioiodine administration). Treatment failure was defined as histopathologically confirmed locoregional recurrence, or radiologically-evident distant metastases (signs of disease on computer tomography (CT) or magnetic resonance imaging (MRI), or abnormal foci of radioiodine or [18F] fluorodeoxyglucose ([18F]FDG) uptake. Results In univariate analysis, Tg1 (p p n = 561) with anti-Tg antibodies titers below the institutional cut-off, 115 IU/mL, Tg1 was an independent prognostic marker. Tg1 and Tg3 cutoffs to best predict structural recurrence were established at 0.7 ng/mL and 1.4 ng/mL, respectively. Conclusions Tg1 and Tg3, measurements made after rhTSH stimulation but before radioiodine treatment, independently predict a low risk of treatment failure in patients with DTC. Levels measured post-radioiodine application (e.g., Tg6) are highly variable, lack prognostic value, and hence can be omitted. |
| تدمد: | 1864-6433 0914-7187 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feaedaf3592f3a4948903ae0f97704e0 https://doi.org/10.1007/s12149-021-01663-y |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....feaedaf3592f3a4948903ae0f97704e0 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18646433 09147187 |
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