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Influence of AIN-93 diet on mortality and cardiac remodeling after myocardial infarction in rats

التفاصيل البيبلوغرافية
العنوان: Influence of AIN-93 diet on mortality and cardiac remodeling after myocardial infarction in rats
المؤلفون: Marcos F. Minicucci, Lidiane P. Ardisson, Ethel L. B. Novelli, Luiz Shiguero Matsubara, Rosangela Novo, Priscila P. Santos, Léa Silvia Sant'Ana, Fernanda Chiuso-Minicucci, Beatriz Bojikian Matsubara, Leonardo A. M. Zornoff, Paula S. Azevedo, Sergio A. R. Paiva, Heloisa Balan Assalin
المساهمون: Universidade Estadual Paulista (Unesp)
المصدر: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
بيانات النشر: Elsevier BV, 2012.
سنة النشر: 2012
مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Sodium, chemistry.chemical_element, Heart failure, Calcium, Random Allocation, chemistry.chemical_compound, Internal medicine, medicine, Animals, Citrate synthase, Myocardial infarction, Rats, Wistar, Nutrition, Minerals, Ventricular Remodeling, biology, business.industry, Insulin, Nutritional Requirements, food and beverages, medicine.disease, Malondialdehyde, Remodeling, Rats, Diet, Endocrinology, chemistry, Coronary occlusion, biology.protein, Rat, Cardiology and Cardiovascular Medicine, business
الوصف: Made available in DSpace on 2013-09-27T14:54:30Z (GMT). No. of bitstreams: 1 WOS000302804900013.pdf: 252282 bytes, checksum: 2973404343f71f98db03232dc31a7a88 (MD5) Previous issue date: 2012-05-03 Made available in DSpace on 2013-09-30T18:38:40Z (GMT). No. of bitstreams: 1 WOS000302804900013.pdf: 252282 bytes, checksum: 2973404343f71f98db03232dc31a7a88 (MD5) Previous issue date: 2012-05-03 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:51:14Z No. of bitstreams: 1 WOS000302804900013.pdf: 252282 bytes, checksum: 2973404343f71f98db03232dc31a7a88 (MD5) Made available in DSpace on 2014-05-20T13:51:14Z (GMT). No. of bitstreams: 1 WOS000302804900013.pdf: 252282 bytes, checksum: 2973404343f71f98db03232dc31a7a88 (MD5) Previous issue date: 2012-05-03 Botucatu Medical School Background: The AIN-93 diet was proposed by the American Institute of Nutrition with the objective of standardising studies in experimental nutrition. Our objective was to analyze the effects of AIN-93 diet after myocardial infarction in rats.Methods: Post weaning, the animals were divided into two groups: control (C, n=62), fed the standard diet of our laboratory (Labina); AIN-93 Group (n=70), fed the AIN-93 diet. Achieving 250 g, the animals were subjected to myocardial infarction.Results: Early mortality was increased in AIN-93 animals, associated with lower serum levels of calcium, magnesium, potassium, sodium, and phosphorus. on the other hand, after 90 days, AIN-93 showed smaller normalized left ventricular dimensions. The caloric and carbohydrate intake was smaller, but the fat intake was higher in AIN-93 rats. AIN-93 group also showed increased levels of beta-hydroxyacylcoenzyme A dehydrogenase and citrate synthase. In addition, serum levels of insulin and cardiac levels of malondialdehyde, metalloproteinases-2 and -9, and TNF-alpha and IFN-gamma were decreased in the AIN-93 group.Conclusion: AIN-93 diet increased early mortality, while attenuated the chronic remodeling process after experimental coronary occlusion. Therefore, this diet has biological effects and should be use with attention in this model. (C) 2010 Elsevier B.V. All rights reserved. UNESP São Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil São Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil UNESP São Paulo State Univ, Botucatu Med Sch, Inst Biol Sci, Dept Chem & Biochem, Botucatu, SP, Brazil UNESP São Paulo State Univ, Fac Agr Sci, Agroind Technol & Management Dept, Botucatu, SP, Brazil UNESP São Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil São Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil UNESP São Paulo State Univ, Botucatu Med Sch, Inst Biol Sci, Dept Chem & Biochem, Botucatu, SP, Brazil UNESP São Paulo State Univ, Fac Agr Sci, Agroind Technol & Management Dept, Botucatu, SP, Brazil
تدمد: 0167-5273
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb281fc89df78612d0bf071d7d6c1f3
https://doi.org/10.1016/j.ijcard.2010.10.128
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....feb281fc89df78612d0bf071d7d6c1f3
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01675273