Assembly of π-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework
| العنوان: | Assembly of π-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework |
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| المؤلفون: | Sherrie L. Heinz-Kunert, Ashma Pandya, Viet Thuc Dang, Phuong Nguyen Tran, Sabari Ghosh, Dan McElheny, Bernard D. Santarsiero, Zhong Ren, Andy I. Nguyen |
| المصدر: | Journal of the American Chemical Society. 144:7001-7009 |
| بيانات النشر: | American Chemical Society (ACS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | 2,2'-Dipyridyl, Colloid and Surface Chemistry, Metals, Proteins, General Chemistry, Peptides, Porosity, Biochemistry, Catalysis |
| الوصف: | The evolution of proteins from simpler, self-assembled peptides provides a powerful blueprint for the design of complex synthetic materials. Previously, peptide-metal frameworks using short sequences (≤3 residues) have shown great promise as proteomimetic materials that exhibit sophisticated capabilities. However, their development has been hindered due to few variable residues and restricted choice of side-chains that are compatible with metal ions. Herein, we developed a noncovalent strategy featuring π-stacking bipyridyl residues to assemble much longer peptides into crystalline frameworks that tolerate even previously incompatible acidic and basic functionalities and allow an unprecedented level of pore variations. Single-crystal X-ray structures are provided for all variants to guide and validate rational design. These materials exhibit hallmark proteomimetic behaviors such as guest-selective induced fit and assembly of multimetallic units. Significantly, we demonstrate facile optimization of the framework design to substantially increase affinity toward a complex organic molecule. |
| تدمد: | 1520-5126 0002-7863 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef6c082464b0da5cbc4967800a4e255 https://doi.org/10.1021/jacs.2c02146 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....fef6c082464b0da5cbc4967800a4e255 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205126 00027863 |
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