Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer
| العنوان: | Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer |
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| المؤلفون: | Jun Li, Fei Zhao, Qian-Ge Wu, Xiao-Yu Yang, Xue-Yun Qin, Chengxiang Zhu, Yue Yu, Qifan Li, Yue Zhou, Liang Chen, Fuxi Zhen, Shu-Hui You, Chenjun Huang, Wei Wang, Liu Yi |
| المصدر: | BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019) BMC Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Pulmonary Surgical Procedures, lcsh:RC254-282, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Non-small cell lung cancer, Surgical oncology, Carcinoma, Non-Small-Cell Lung, Genetics, medicine, Humans, Stage (cooking), Lung cancer, Lymph node, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, business.industry, Regional lymph node, Multivariable logistic regression, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Dissection, Logistic Models, 030104 developmental biology, medicine.anatomical_structure, Oncology, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Mediastinal lymph node, Lymph Node Excision, Female, Radiology, Lymph, business, Research Article |
| الوصف: | Background Selection of the best lymph node for dissection is a controversial topic in clinical stage-I non-small cell lung cancer (NSCLC). Here, we sought to identify the clinicopathologic predictors of regional lymph node metastasis in patients intraoperatively diagnosed with stage-I NSCLC. Methods A retrospective review of 595 patients intraoperatively diagnosed as stage I non-small-cell lung cancer who underwent lobectomy with complete lymph node dissection was performed. Univariate and multivariable logistic regression analysis was performed to determine the independent predictors of regional lymph node metastasis. Results Univariate logistic regression and multivariable analysis revealed three independent predictors of the presence of metastatic hilar lymph nodes, five independent predictors for lobe specific mediastinal lymph nodes, two independent predictors for lobe nonspecific mediastinal lymph nodes and two independent predictors for skipping mediastinal lymph nodes. Conclusions A complete mediastinal lymph node dissection may be considered for patients suspected of nerve invasion and albumin (> 43.1 g/L) or nerve and vascular invasions. Lobe-specific lymph node dissection should probably be performed for patients suspected of pulmonary membrane invasion, vascular invasion, CEA (> 2.21 ng/mL), and tumor (> 1.6 cm) in the right lower lobe or mixed lobes. Hilar lymph node dissection should probably be performed for patients suspected of having bronchial mucosa and cartilage invasion, vascular invasion, and CEA (> 2.21 ng/mL). Electronic supplementary material The online version of this article (10.1186/s12885-019-5632-2) contains supplementary material, which is available to authorized users. |
| تدمد: | 1471-2407 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1a16501b262e3b3bea70c502ce4fce https://doi.org/10.1186/s12885-019-5632-2 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ff1a16501b262e3b3bea70c502ce4fce |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712407 |
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