Role of alcohol and smoking in diagnostic delay of head and neck cancer patients
| العنوان: | Role of alcohol and smoking in diagnostic delay of head and neck cancer patients |
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| المؤلفون: | Rob J. de Leeuw, Jacques A. M. Winnubst, G. J. Hordijk, Xavier D. R. Brouha, D. M. Tromp |
| المصدر: | Acta Oto-Laryngologica. 125:552-556 |
| بيانات النشر: | Informa UK Limited, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Larynx, medicine.medical_specialty, Alcohol Drinking, Diagnosis, Differential, Internal medicine, Humans, Medicine, Risk factor, Laryngeal Neoplasms, Aged, Neoplasm Staging, Aged, 80 and over, Mouth, Heavy drinking, business.industry, Large tumour, Smoking, Head and neck cancer, Pharynx, Cancer, Pharyngeal Neoplasms, General Medicine, Middle Aged, medicine.disease, Surgery, medicine.anatomical_structure, Otorhinolaryngology, Carcinoma, Squamous Cell, T-stage, Female, Mouth Neoplasms, business |
| الوصف: | This study shows that heavy drinking is a risk factor for prolonged delay in presenting with head and neck cancer and for presenting with a large tumour in the head and neck region. Excessive smoking is only a risk factor for being diagnosed with a large tumour, although there is a weak association between smoking and prolonged diagnostic delay.It is reasonable to assume that prolonged delay in presenting with head and neck cancer is associated with an advanced stage of cancer at diagnosis. In this study we analysed the effects of drinking and smoking habits on diagnostic delay and the T stage of the tumour at diagnosis.A total of 427 patients with newly diagnosed head and neck carcinomas were eligible for this study. Of these, 306 (72%) actually participated: 134 (77%) with an oral tumour; 117 (69%) with a larynx tumour; and 55 (65%) with a pharynx tumour. Diagnostic delay was defined as a period of30 days between the appearance of the first tumour-related symptoms and the first visit to a physician. T3 4 tumours were defined as advanced tumours. Drinking behaviour was classified into three types: light (0 2 drinks/day); moderate (3 4 drinks/day); and heavy (4 drinks/day). Smoking habits were classified into 4 types: never; stopped; light (0 20 cigarettes/day); and heavy (20 cigarettes/day).Logistic regression showed that there were significantly more heavy than light drinkers [p = 0.04; odds ratio (OR) 1.8; 95% CI 1.0-3.1] in the delay group than in the non-delay group. Light smokers showed a tendency towards prolonged delay (p = 0.06; OR 2.2; 95% CI 1.0-5.0). Both heavy drinking (p = 0.01; OR 2.0; 95% CI 1.2-3.6) and heavy smoking (p = 0.03; OR 3.1; 95% CI 1.1-8.4) were risk factors for a patient to be diagnosed with a large tumour. |
| تدمد: | 1651-2251 0001-6489 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2aa359b6e87d87aa742111809bbbe2 https://doi.org/10.1080/00016480510028456 |
| رقم الأكسشن: | edsair.doi.dedup.....ff2aa359b6e87d87aa742111809bbbe2 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 16512251 00016489 |
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