The systemic toxicity of heavy metal mixtures in rats
| العنوان: | The systemic toxicity of heavy metal mixtures in rats |
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| المؤلفون: | Hong Su, Yuanliang Gu, Jinshun Zhao, Min Ding, Xin Song, Qihang Hua, Samuel Selorm Fiati Kenston, Joni Aldinger, Xialu Lin, Tabatha Barber, Zhen Li, Lu Kong, Yafei Wang, Zhou Li |
| المصدر: | Toxicology Research |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Cadmium, Health, Toxicology and Mutagenesis, Chloral hydrate, chemistry.chemical_element, Morris water navigation task, Zinc, 010501 environmental sciences, Toxicology, 01 natural sciences, Chemistry, 03 medical and health sciences, Chromium, chemistry.chemical_compound, 030104 developmental biology, chemistry, Lead acetate, Oral administration, medicine, Potassium dichromate, 0105 earth and related environmental sciences, Nuclear chemistry, medicine.drug |
| الوصف: | To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose of heavy metal mixtures (HMMs). To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose of heavy metal mixtures (HMMs). The eight most common detectable heavy metals in Ningbo area are zinc (Zn), copper (Cu), manganese (Mn), chromium (Cr), nickel (Ni), cadmium (Cd), lead (Pb) and mercury (Hg). In this study, mixtures of these eight heavy metals were prepared using the compounds zinc sulfate heptahydrate, cupric sulfate, manganese dichloride, potassium dichromate, nickel dichloride, cadmium dichloride, lead acetate, and methyl mercury chloride with ion mass proportions of 1070.0, 312.6, 173.1, 82.6, 30.0, 13.3, 6.6, and 1.0, respectively. The rats were randomly divided into four groups. Beside the control group, each rat received a corresponding dose of HMMs 215, 464 or 1000 mg per kg body weight (bwt), respectively. The rats were observed for 4 weeks. During the last week of observation, the Morris water maze test was used to investigate spatial learning and memory in the treated rats. The rats were exsanguinated under complete chloral hydrate anesthesia and organ coefficients were measured. Biochemical tests of blood and serum samples were carried out. The results showed abnormalities in the hematological system, decreased renal function, hepatic injury and disturbances in the electrolyte balance of the rats treated with a high dose of HMMs. Death of some rats was also observed. This paper analyzed how a one-time high dose oral administration of HMMs induced systemic toxicity. |
| تدمد: | 2045-4538 2045-452X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff446996c8bb31b2d36806eb66ffbbc1 https://doi.org/10.1039/c7tx00260b |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ff446996c8bb31b2d36806eb66ffbbc1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20454538 2045452X |
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