The effect of ellagic acid on the repair process of periodontal defects related to experimental periodontitis in rats
| العنوان: | The effect of ellagic acid on the repair process of periodontal defects related to experimental periodontitis in rats |
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| المؤلفون: | Figen Öngöz Dede, Meryem Akpolat Ferah, Bahattin Avci, Şeyma Bozkurt Doğan, Mustafa Cenk Durmuşlar, Umut Balli, Kanat Gulle |
| المساهمون: | İstanbul Kent Üniversitesi, Fakülteler, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü, Durmuşlar, Mustafa Cenk, BALLI, UMUT |
| المصدر: | Journal of Applied Oral Science, Vol 29 (2021) Journal of Applied Oral Science Journal of Applied Oral Science v.29 2021 Journal of applied oral science Universidade de São Paulo (USP) instacron:USP Journal of Applied Oral Science, Volume: 29, Article number: e20210160, Published: 27 SEP 2021 |
| بيانات النشر: | University of São Paulo, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Ellagic acid, Periodontal repair, Interleukin-1beta, Alveolar Bone Loss, medicine.disease_cause, chemistry.chemical_compound, Internal medicine, medicine, Animals, Rats, Wistar, Periodontitis, General Dentistry, Dental alveolus, biology, business.industry, Tumor Necrosis Factor-alpha, Interleukin, RK1-715, Glutathione, medicine.disease, Resorption, Rats, Endocrinology, Alveolar bone defect, chemistry, Clinical attachment loss, Myeloperoxidase, Dentistry, biology.protein, Cytokines, Original Article, Antioxidant, business, Oxidative stress |
| الوصف: | Objective: This study aims to evaluate the effect of ellagic acid (EA) by measuring the levels of alveolar bone resorption and inflammatory and oxidative stress markers in the periodontal tissues and serum on the periodontal repair process related to experimental periodontitis in rats. Methodology: Forty Wistar rats were divided into four study groups as follows: Group 1=healthy control (n=10); Group 2=EA control (15 mg/kg)(n=10); Group 3=periodontitis (n=10); Group 4=periodontitis+EA (15 mg/kg) (n=10). The periodontitis model was established by ligating bilateral mandibular first molars for 14 days. Then, rats were given normal saline or EA for another 14 days by gavage administration. Serum and gingiva myeloperoxidase (MPO) activity, 8-hydroxydeoxyguanosine(8-OHdG), and glutathione (GSH) levels were analyzed by ELISA. İmmunohistochemical analysis was used to detect Interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-α) immunoreactivities in the periodontal tissues. Alveolar bone loss (ABL) and attachment loss (AL) was evaluated by histomorphometry analysis. Results: ABL and AL were statistically higher in group 3 than in groups 1, 2 and 4 and in group 4 than in groups 1 and 2 (p |
| وصف الملف: | application/pdf; text/html |
| اللغة: | English |
| تدمد: | 1678-7765 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff830fe5fbed2edd466430ccd9140c6d http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572021000100443&tlng=en |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ff830fe5fbed2edd466430ccd9140c6d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16787765 |
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