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Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum

التفاصيل البيبلوغرافية
العنوان: Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum
المؤلفون: Ashley D. Harris, Carly A. McMorris, Sakshi Kaur, Svenja Espenhahn, Kara Murias, Olesya Dmitrieva, Charlene Wright, Adam W. McCrimmon, Niloy Nath, Kate J. Godfrey, Signe Bray, Andrea B. Protzner, Filomeno Cortese, Deborah Dewey, Maia Ross
المصدر: Molecular Autism
Molecular Autism, Vol 12, Iss 1, Pp 1-18 (2021)
بيانات النشر: BioMed Central, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Male, medicine.medical_specialty, Autism, Context (language use), Audiology, Electroencephalography, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, Developmental Neuroscience, Somatosensory-evoked potentials, Evoked Potentials, Somatosensory, medicine, Humans, 0501 psychology and cognitive sciences, EEG, Adaptation, Autistic Disorder, 10. No inequality, Child, Molecular Biology, Children, lcsh:Neurology. Diseases of the nervous system, Tactile stimulation, Sensory stimulation therapy, medicine.diagnostic_test, Research, Tactile sensitivities, 05 social sciences, Neuropsychology, Cognition, Somatosensory Cortex, medicine.disease, Psychiatry and Mental health, Somatosensory evoked potential, Touch, Child, Preschool, Female, Psychology, 030217 neurology & neurosurgery, Neurotypical, ERP, 050104 developmental & child psychology, Developmental Biology
الوصف: Background Unusual behavioral reactions to sensory stimuli are frequently reported in individuals on the autism spectrum (AS). Despite the early emergence of sensory features ( Methods Here, we used electroencephalography (EEG) to investigate tactile cortical processing in young children aged 3–6 years with autism and in neurotypical (NT) children. Scalp EEG was recorded from 33 children with autism, including those with low cognitive and/or verbal abilities, and 45 age- and sex-matched NT children during passive tactile fingertip stimulation. We compared properties of early and later somatosensory-evoked potentials (SEPs) and their adaptation with repetitive stimulation between autistic and NT children and assessed whether these neural measures are linked to “real-world” parent-reported tactile reactivity. Results As expected, we found elevated tactile reactivity in children on the autism spectrum. Our findings indicated no differences in amplitude or latency of early and mid-latency somatosensory-evoked potentials (P50, N80, P100), nor adaptation between autistic and NT children. However, latency of later processing of tactile information (N140) was shorter in young children with autism compared to NT children, suggesting faster processing speed in young autistic children. Further, correlational analyses and exploratory analyses using tactile reactivity as a grouping variable found that enhanced early neural responses were associated with greater tactile reactivity in autism. Limitations The relatively small sample size and the inclusion of a broad range of autistic children (e.g., with low cognitive and/or verbal abilities) may have limited our power to detect subtle group differences and associations. Hence, replications are needed to verify these results. Conclusions Our findings suggest that electrophysiological somatosensory cortex processing measures may be indices of “real-world” tactile reactivity in early childhood autism. Together, these findings advance our understanding of the neurophysiological mechanisms underlying tactile reactivity in early childhood autism and, in the clinical context, may have therapeutic implications.
اللغة: English
تدمد: 2040-2392
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffcebfc604b6e1dd251d1faee34c8714
http://europepmc.org/articles/PMC8017878
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....ffcebfc604b6e1dd251d1faee34c8714
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20402392