Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma
| العنوان: | Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma |
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| المصدر: | Blood. 110(9):3112-3121 |
| بيانات النشر: | AMER SOC HEMATOLOGY, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | SOUTHERN BLOT ANALYSIS, ISOTYPE SWITCH EVENTS, LIGHT-CHAIN, B-CELL REPERTOIRE, CHRONIC LYMPHOCYTIC-LEUKEMIA, INCOMPLETE DJH REARRANGEMENTS, CHAIN VARIABLE REGION, SOMATIC HYPERMUTATION, ALLELIC EXCLUSION, V-H GENES |
| الوصف: | The ability to rearrange the germ-line DNA to generate antibody diversity is an essential prerequisite for the production of a functional repertoire. While this is essential to prevent infections, it also represents the "Achilles heal" of the B-cell lineage, occasionally leading to malignant transformation of these cells by translocation of protooncogenes into the immunoglobulin (Ig) loci. However, in evolutionary terms this is a small price to pay for a functional immune system. The study of the configuration and rearrangements of the Ig gene loci has contributed extensively to our understanding of the natural history of development of myeloma. In addition to this, the analysis of Ig gene rearrangements in B-cell neoplasms provides information about the clonal origin of the disease, prognosis, as well as providing a clinical useful tool for clonality detection and minimal residual disease monitoring. Herein, we review the data currently available on both Ig gene rearrangements and protein patterns seen in myeloma with the aim of illustrating how this knowledge has contributed to our understanding of the pathobiology of myeloma. |
| اللغة: | English |
| تدمد: | 1528-0020 0006-4971 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dris___01423::4a825a6fa94c9a66b54b311ed1da4487 https://doi.org/10.1182/blood-2007-02-069625 |
| رقم الأكسشن: | edsair.dris...01423..4a825a6fa94c9a66b54b311ed1da4487 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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