Immunomodifying and neuroprotective effects of noscapine
| العنوان: | Immunomodifying and neuroprotective effects of noscapine |
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| المصدر: | Chemico-Biological Interactions. 352 |
| بيانات النشر: | Elsevier Ireland Ltd, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Noscapine, Bradykinin/metabolism, NF-KAPPA-B, Oligodendroglia/drug effects, MECHANISMS, Multiple sclerosis, CEREBROSPINAL-FLUID, Signal Transduction/drug effects, Neurodegenerative Diseases/drug therapy, Receptors, Histamine Antagonists/pharmacology, Ion Channels/drug effects, INJURY, Animals, Humans, Immunomodulating Agents/pharmacology, Alzheimer 's disease, CA2+-ACTIVATED K+ CHANNELS, NF-KappaB, G-Protein-Coupled/metabolism, Alzheimer Disease/drug therapy, RECEPTOR, Amyotrophic lateral sclerosis, Mental Disorders/drug therapy, Parkinson 's disease, Amyotrophic Lateral Sclerosis/drug therapy, Multiple Sclerosis/drug therapy, Parkinsonian Disorders/drug therapy, INHIBITORS, Neuroprotective Agents/pharmacology, Stroke/drug therapy, Noscapine/administration & dosage |
| الوصف: | Noscapine is a phthalide isoquinoline alkaloid with antitussive activity. Noscapine protects oligodendroglia from ischemic and chemical injury, binds to bitter taste receptors, antagonizes the bradykinin and histaminergic systems, which may be of benefit in treatment of multiple sclerosis. Noscapine normalizes axonal transport and exerts significant therapeutic efficacy in animal models of Parkinson's Disease and Amyotrophic Lateral Sclerosis. Noscapine exerts neuroprotective effects on oxygen- and glucose-deprived fetal cortical neuronal cells and reduces ischemic brain damage in neonatal rat pups. Pilot clinical studies indicated some beneficial effects of noscapine in stroke. Noscapine harbours anxiolytic activity and methyl-noscapine blocks small conductance SK channels, which is beneficial in alleviating anxiety and depression. Noscapine exerts anticholinesterase activity and acts inhibitory on the inflammatory transcription factor NF-κB, which may be harnessed in treatment of Alzheimer's Disease. With its blood-brain barrier traversing features and versatile actions, noscapine may be a promising agent in the armamentarium against neurodegenerative and psychiatric diseases. |
| اللغة: | English |
| تدمد: | 1872-7786 0009-2797 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=od________83::7eda232dee01c546a75cc72003b632b6 https://doi.org/10.1016/j.cbi.2021.109794 |
| رقم الأكسشن: | edsair.od........83..7eda232dee01c546a75cc72003b632b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18727786 00092797 |
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