التفاصيل البيبلوغرافية
العنوان:
Production of Odd-Carbon Dicarboxylic Acids in Escherichia coli Using an Engineered Biotin-Fatty Acid Biosynthetic Pathway
المؤلفون:
Haushalter, RW , Phelan, RM , Hoh, KM , Su, C , Wang, G , Baidoo, EEK , Keasling, JD
المصدر:
Haushalter, RW; Phelan, RM; Hoh, KM; Su, C; Wang, G; Baidoo, EEK; et al.(2017). Production of Odd-Carbon Dicarboxylic Acids in Escherichia coli Using an Engineered Biotin-Fatty Acid Biosynthetic Pathway. Journal of the American Chemical Society, 139(13), 4615-4618. doi: 10.1021/jacs.6b11895. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/92n963qq
بيانات النشر:
eScholarship, University of California, 2017.
سنة النشر:
2017
الوصف:
© 2017 American Chemical Society. Dicarboxylic acids are commodity chemicals used in the production of plastics, polyesters, nylons, fragrances, and medications. Bio-based routes to dicarboxylic acids are gaining attention due to environmental concerns about petroleum-based production of these compounds. Some industrial applications require dicarboxylic acids with specific carbon chain lengths, including odd-carbon species. Biosynthetic pathways involving cytochrome P450-catalyzed oxidation of fatty acids in yeast and bacteria have been reported, but these systems produce almost exclusively even-carbon species. Here we report a novel pathway to odd-carbon dicarboxylic acids directly from glucose in Escherichia coli by employing an engineered pathway combining enzymes from biotin and fatty acid synthesis. Optimization of the pathway will lead to industrial strains for the production of valuable odd-carbon diacids.
وصف الملف:
application/pdf
اللغة:
English
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=od_______325::41d3eb1d4cb6e52edc8eb77a8a47673f http://www.escholarship.org/uc/item/92n963qq
حقوق:
OPEN
رقم الأكسشن:
edsair.od.......325..41d3eb1d4cb6e52edc8eb77a8a47673f
قاعدة البيانات:
OpenAIRE
