التفاصيل البيبلوغرافية
| العنوان: |
A two-component regulatory system modulates twitching motility in Dichelobacter nodosus |
| المؤلفون: |
Kennan, RM, Lovitt, CJ, Han, X, Parker, D, Turnbull, L, Whitchurch, CB, Rood, JI |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Dichelobacter nodosus, Mutagenesis, Insertional, Sheep, Virulence, Fimbriae, Bacterial, Chemotaxis, Animals, Sheep Diseases, Veterinary Sciences, Gram-Negative Bacterial Infections, Foot Rot, Signal Transduction |
| الوصف: |
© 2015 Elsevier B.V. All rights reserved. Dichelobacter nodosus is the essential causative agent of footrot in sheep and type IV fimbriae-mediated twitching motility has been shownto be essential for virulence.Wehave identified a two-component signal transduction system (TwmSR) that shows similarity to chemosensory systems from other bacteria. Insertional inactivation of the gene encoding the response regulator, TwmR, led to a twitching motility defect, with the mutant having a reduced rate of twitching motility when compared to the wild-type and a mutant complemented with the wild-type twmR gene. The reduced rate of twitching motility was not a consequence of a reduced growth rate or decreased production of surface located fimbriae, but video microscopy indicated that it appeared to result from an overall loss of twitching directionality. These results suggest that a chemotactic response to environmental factors may play an important role in the D. nodosus-mediated disease process. |
| وصف الملف: |
application/pdf |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=od_______363::7669bb8e3c26a15d2538fdeb3258786e
https://hdl.handle.net/10453/41113 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.od.......363..7669bb8e3c26a15d2538fdeb3258786e |
| قاعدة البيانات: |
OpenAIRE |
