Antigen presentation to t-lymphocyte in the induction of immune response
| العنوان: | Antigen presentation to t-lymphocyte in the induction of immune response |
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| المؤلفون: | Zdenko Kovač |
| المصدر: | Medicinski vjesnik Volume 22 Issue (1-2) |
| بيانات النشر: | Scientific Unit for Clinical and Medical Research, Osijek University Hospital, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | antigen, imunopredočavanje, limfocit T, antigen-presenting cells, T cells |
| الوصف: | Pokretanje imunosnog odgovora limfocita T stranim antigenom, predstavlja niz staničnih i molekulskih interakcija. Prvi korak u pokretanju imunosne reakcije je prerada strane molekule u imunopredočnim stanicama domaćina. Noviji pokusi su otkrili biokemijske detalje prerade antigena u imunopredočnim stanicama. Iako su većim dijelom rezultati dobiveni posrednim metodama stanične i molekulske analize, pokusi čvrsto ukazuju da su otkrivanje epitopa antigena i/ili povećano usjedanje u lipofilni medij membrane osnovni biokemijski zahtjevi u obradi antigena. Prerađena molekula se potom veže na molekulu glavnog kompleksa tkivne snošljivosti (GSTS), koja time djeluje kao površinski stanični receptor. Molekule i prvog i drugog razreda GSTS se ponašaju kao receptori za prerađene antigene. Stvaranje imunogeničnih kompleksa između antigenskih peptida i molekula tkivne snošljivosti događa se prije njihova prepoznavanja od strane limfocita T. To dvojno istodobno prepoznavanje receptorom osnova je fenomenologije GSTS-spregnutosti imunosnog odgovora limfocita T. Također, vezivanje ili odsutnost vezivanja novonastalih peptida predstavlja jednu od razina funkcije gena imunosnog odgovora (Ir-geni). Stoga su imunobiološki fenomeni spregnutosti i Ir-genske funkcije prodiskutirani u svjetlu novih spoznaja o preradi i imunopredočavanju antigena. Activation of the T lymphocyte response by a foreign antigen comprises a set of cellular and molecular interactions. Recently published experiments have revealed the biochemical basis of antigen processing and presentation by antigen presenting cells. The exposititon of the epitope and/or an increased partition into the lipid membrane are considered minimal biochemical requirements of antigen processing. Processed antigenic peptide binds to a major histocompatibility molecule, which therewith acts as a cell surface receptor. This holds for both class one and class two MHC restricted responses. The formation of immune complexes between the processed peptide and major histocompatibility molecule takes place before their recognition by the T cell receptor, and it is independent of its presence. Cognate antigen-MHC molecule recognition by the cell receptor is a molecular fondation of the phenomenology of MHC restricted T cell responses, and it functions as one level of the immune response (Ir) gene function. These phenomena are therefore briefly discussed in the context of our contemporary understanding of antigen processing and presentation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0350-6487 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=od_______951::1c5d49540fa4b1ee3692cd8b95a8d089 https://hrcak.srce.hr/file/289207 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.od.......951..1c5d49540fa4b1ee3692cd8b95a8d089 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03506487 |
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