Association between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer
| العنوان: | Association between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer |
|---|---|
| المؤلفون: | Fridley, BL, Goode, EL, Høgdall, E, Jensen, A, Cass, I, Kjær, SK, Johnatty, SE, Nicoletto, MO, D'Andrea, E, Montagna, M, Blanco, I, Lázaro, C, Ma, ESK, Daly, MB, Godwin, AK, Eeles, R, Evans, DG, Frost, D, Peock, S, Hartge, P, Gail, MH, Neuhausen, S, García, MJ, Benítez, J, Sinilnikova, O, Easton, DF, Healey, S, McGuffog, L, Barrowdale, D, Despierre, E, Lambrechts, D, Karlan, BY, Ramus, SJ, Sadetzki, S, Goh, C, ChenevixTrench, G, Bolton, KL, Li, AJ, Walsh, C, Gross, J, Steele, L, Beattie, MS, Chan, S, Nussbaum, RL, Moysich, KB, Leuchter, R, Borg, Å, Olsson, H, Kristoffersson, U, Sieh, W, McGuire, V, Whittemore, AS, Tyrer, J, Song, H, Michie, CO, Gourley, C, Gore, ME, Senter, L, Toland, AE, Glendon, G, HirshYechezkel, G, Lubin, F, Chetrit, A, Mai, PL, Greene, MH, Loud, JT, Levine, DA, Gordon, O, GarciaClosas, M, Gayther, SA, Chanock, SJ, Antoniou, AC, Pharoah, PDP, Andrulis, IL, Kwong, A |
| بيانات النشر: | American Medical Association. The Journal's web site is located at http://jama.ama-assn.org/index.dtl, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | endocrine system diseases, skin and connective tissue diseases, female genital diseases and pregnancy complications |
| الوصف: | Context: Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear. Objective: To characterize the survival of BRCA carriers with EOC compared with noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar survival patterns. Design, Setting, and Participants: A pooled analysis of 26 observational studies on the survival of women with ovarian cancer, which included data from 1213 EOC cases with pathogenic germline mutations in BRCA1 (n=909) or BRCA2 (n=304) and from 2666 noncarriers recruited and followed up at variable times between 1987 and 2010 (the median year of diagnosis was 1998). Main Outcome Measure: Five-year overall mortality. Results: The 5-year overall survival was 36% (95% CI, 34%-38%) for noncarriers, 44% (95% CI, 40%-48%) for BRCA1 carriers, and 52% (95% CI, 46%-58%) for BRCA2 carriers. After adjusting for study and year of diagnosis, BRCA1 and BRCA2 mutation carriers showed amore favorable survival than noncarriers (for BRCA1: hazard ratio [HR], 0.78; 95% CI, 0.68-0.89; P link_to_OA_fulltext |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=od_______961::26300e4c4ad8b29c56279357f406856d http://hdl.handle.net/10722/182264 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.od.......961..26300e4c4ad8b29c56279357f406856d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |