التفاصيل البيبلوغرافية
| العنوان: |
Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis |
| المؤلفون: |
Dimopoulos, G. de Mast, Q. Markou, N. Theodorakopoulou, M. Komnos, A. Mouktaroudi, M. Netea, M.G. Spyridopoulos, T. Verheggen, R.J. Hoogerwerf, J. Lachana, A. van de Veerdonk, F.L. Giamarellos-Bourboulis, E.J. |
| سنة النشر: |
2020 |
| الوصف: |
Complex immune dysregulation in severe COVID-19 suggests the use of immunomodulation therapies. Dimopoulos et al. describe eight cases of COVID-19 patients who all had secondary hemophagocytic lymphohistiocytosis and showed favorable responses in respiratory function upon treatment with the interleukin-1 receptor antagonist Anakinra. © 2020 Elsevier Inc. Dysregulation of inflammation is hypothesized to play a crucial role in the severe complications of COVID-19, with the IL-1/IL-6 pathway being central. Here, we report on the treatment of eight severe COVID-19 pneumonia patients—seven hospitalized in intensive care units (ICUs) in Greece and one non-ICU patient in the Netherlands—with the interleukin-1 receptor antagonist Anakinra. All patients scored positive for the hemophagocytosis score (HScore) and were diagnosed with secondary hemophagocytic lymphohistocytosis (sHLH) characterized by pancytopenia, hyper-coagulation, acute kidney injury, and hepatobiliary dysfunction. At the end of treatment, ICU patients had less need for vasopressors, significantly improved respiratory function, and lower HScore. Although three patients died, the mortality was lower than historical series of patients with sHLH in sepsis. These data suggest that administration of Anakinra may be beneficial for treating severe COVID-19 patients with sHLH as determined by the HScore, and they support the need for larger clinical studies to validate this concept. © 2020 Elsevier Inc. |
| اللغة: |
English |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=od______2127::0147b23bb273bc593e27642729377767
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3000174 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.od......2127..0147b23bb273bc593e27642729377767 |
| قاعدة البيانات: |
OpenAIRE |
