التفاصيل البيبلوغرافية
| العنوان: |
Osteonectin as a screening marker for pancreatic cancer: A prospective study |
| المؤلفون: |
Papapanagiotou, A. Sgourakis, G. Karkoulias, K. Raptis, D. Parkin, E. Brotzakis, P. Panchal, S. Papavassiliou, A.G. |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
musculoskeletal system |
| الوصف: |
Objective: Osteonectin plays a central role in various processes during the development of pancreatic adenocarcinoma. This prospective pilot study was performed to determine the feasibility of serum osteonectin as a screening tool for pancreatic cancer. Methods: Blood samples were collected from 15 consecutive patients with newly diagnosed pancreatic cancer and 30 matched healthy controls. Serum osteonectin was measured using an osteonectin enzyme-linked immunosorbent assay kit. The primary outcomes were the diagnostic performance of serum osteonectin and the threshold value for differentiation of patients from controls. Results: The median/quartile range of serum osteonectin in patients and controls were 306.8/288.5 ng/mL and 67.5/39.8 ng/mL, respectively. Osteonectin concentrations significantly differed among the study groups. A plasma osteonectin concentration of >100.18 ng/mL as selected by the receiver operating characteristic curves demonstrated an estimated area under the curve of 86% for prediction of pancreatic cancer. Tumour size was a significant predictor of serum osteonectin. A statistically significant difference in serum osteonectin between T1/T2 and T3/T4 tumours was found. Post-hoc comparisons revealed statistically significant differences in the serum osteonectin among the control, T1/T2, and T3/T4 groups. Conclusion: Osteonectin may be used as a screening tool for pancreatic cancer, although this must be validated in prospective studies. © The Author(s) 2018. |
| اللغة: |
English |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=od______2127::883d124eee4e0354a4b273dfc9ada29a
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3086491 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.od......2127..883d124eee4e0354a4b273dfc9ada29a |
| قاعدة البيانات: |
OpenAIRE |
