| الوصف: |
Spontaneous babesiosis in dogs is one of the most common anddangerous diseases. Erythrocyte damage conditioned upon pathogens is a triggerfor hematological complications and lesions of the microcirculatory tract. Thedevelopment of thrombotic processes leads to irreversible changes and subsequentdeath of the organism. The liver is one of the first organs to suffer damage. The aim of the study was to identify the links between the pathogenesis ofhepatopathy and hematological disorders in the course of acute spontaneousbabesiosis in dogs. To achieve this, two groups of dogs of 20 individuals wereformed: the experimental group – animals with babesiosis, the control group –clinically healthy. It is established that acute spontaneous babesiosis occurs insuccessive forms – anemic and jaundice. Normochromic anemia, leukocytosis,thrombocytopenia were detected. Hemorheological parameters indicate increasedaggregation of erythrocytes and platelets, which led to thrombotic conditions. Thecriterion of shock is established – decrease in the volume of circulating blood; its deficiency was 24% for anemic and 34% for jaundice. Also identified markers ofdisseminated intravascular coagulation syndrome (DIC) – hypofibrinogenemia,increased levels of soluble fibrin-monomer complexes, fibrin degradationproducts, including D-dimer. Changes in indicators increased as the disease progressed from anemic to jaundiced form. In the anemic form, shock is definedas subcompensated in moderate severity, and DIC syndrome – in the stage ofconsumption coagulopathy. Complications characterise a transitional state thatis in unstable equilibrium. In the icteric form, shock is defined as decompensatedsevere, and DIC syndrome – in the stage of hypocoagulation. This conditionis characterised as critical, with a pronounced tendency to irreversibility.Changes in liver parameters indicate hyperactivity of all indicator enzymes,hyperbilirubinemia and hyperuria. With the development of the disease, therates increase significantly. DIC syndrome, shock and hepatopathy enter thevicious circle, in which hematological complications cause hepatopathy, andit, in turn, exacerbates them. Hepatopathy for babesiosis in dogs is considereda serious condition that requires intensive care |
